{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T18:58:30Z","timestamp":1780772310969,"version":"3.54.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Natural Science Funding of Shaanxi Province","award":["2015JM8436"],"award-info":[{"award-number":["2015JM8436"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    Formaldehyde (FA), a ubiquitous environmental contaminant, has long been suspected of causing lung injury. However, the molecular and cellular mechanisms underlying this phenomenon remain elusive. The aim of this study was to elucidate the role of autophagy in lung injury induced by FA inhalation. In this study, lung weight coefficient, interleukin 8 in bronchoalveolar fluid, and histopathological examination were used to evaluate the lung injury. Moreover, electron microscopy, Western blotting for the ratio of LC3-II\/LC3-I were used to detect autophagy in lung tissues. Our results indicated that the lung toxicity of FA inhalation is dose dependent. Lung weight coefficient, inflammatory response, and histopathological structure in the 0.5 mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    FA exposure group showed no obvious changes compared with the control. However, exposure to 5 and 10 mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    FA produced lung injury including pulmonary edema, histological changes, and inflammatory responses. Furthermore, the alterations of autophagy correlated with lung injury. Taken together, these data indicate that FA exposure triggers autophagy of alveolar epithelial cells, which might play a pivotal role in lung injury.\n                  <\/jats:p>","DOI":"10.1177\/0748233718796347","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T23:47:00Z","timestamp":1540511220000},"page":"834-841","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Formaldehyde inhalation triggers autophagy in rat lung tissues"],"prefix":"10.1177","volume":"34","author":[{"given":"Qiu-ping","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathology, Medical School, Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Third Ward of VIP, 323 Hospital of PLA, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8071-0947","authenticated-orcid":false,"given":"Dang-xia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical School, Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo-qi","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical School, Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical School, Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical School, Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical School, Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"bibr1-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00128.2016"},{"key":"bibr2-0748233718796347","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.72"},{"key":"bibr3-0748233718796347","doi-asserted-by":"publisher","DOI":"10.4161\/auto.22783"},{"key":"bibr4-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1038\/srep35857"},{"key":"bibr6-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.11.011"},{"key":"bibr5-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.09.026"},{"key":"bibr7-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2011.07.003"},{"issue":"6","key":"bibr8-0748233718796347","first-page":"466","volume":"23","author":"Fan W","year":"2006","journal-title":"Journal of Environmental and Occupational Medicine"},{"key":"bibr9-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1177\/0748233715592992"},{"key":"bibr10-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21910"},{"key":"bibr11-0748233718796347","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00083"},{"key":"bibr12-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.070"},{"key":"bibr13-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.08.029"},{"key":"bibr14-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2007.05.001"},{"key":"bibr15-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.080"},{"key":"bibr16-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179231"},{"key":"bibr17-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.03.011"},{"key":"bibr18-0748233718796347","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2013.845626"},{"key":"bibr19-0748233718796347","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3577"},{"key":"bibr20-0748233718796347","volume-title":"Chinese National Standard: Occupational Exposure Limits for Hazardous Agents in the Workplace (GBZ2.1-2007)","author":"MOH","year":"2007"},{"key":"bibr21-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2015.12.054"},{"key":"bibr22-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201512-2468SO"},{"key":"bibr23-0748233718796347","first-page":"1","volume":"88","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2006","journal-title":"Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"bibr24-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1389823"},{"key":"bibr25-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200909-101JS"},{"key":"bibr26-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1177\/0748233709106824"},{"key":"bibr27-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00555.2016"},{"key":"bibr28-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-007-0182-9"},{"key":"bibr29-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2009.06.002"},{"key":"bibr30-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.10.016"},{"key":"bibr31-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.02.011"},{"issue":"11","key":"bibr32-0748233718796347","first-page":"2012","volume":"125","author":"Xu YL","year":"2012","journal-title":"Chinese Medical Journal (English)"},{"issue":"3","key":"bibr33-0748233718796347","first-page":"164","volume":"18","author":"Yang YH","year":"2005","journal-title":"Biomedical and Environmental Sciences"},{"issue":"3","key":"bibr34-0748233718796347","first-page":"310","volume":"2","author":"Yang YH","year":"2007","journal-title":"Asian Journal of Ecotoxicology"},{"issue":"3","key":"bibr35-0748233718796347","first-page":"38","volume":"25","author":"Zhang XB","year":"2007","journal-title":"Chinese Journal Clinical Anatomy"},{"key":"bibr36-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2006.00198.x"},{"key":"bibr37-0748233718796347","doi-asserted-by":"publisher","DOI":"10.1177\/0748233710393401"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233718796347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0748233718796347","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233718796347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:41:42Z","timestamp":1777668102000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233718796347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,25]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1177\/0748233718796347"],"URL":"https:\/\/doi.org\/10.1177\/0748233718796347","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,25]]}}}