{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:33:37Z","timestamp":1777923217908,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Department of Science and Technology, Ministry of Science and Technology","award":["No. DST\/INSPIRE Fellowship\/2014\/51"],"award-info":[{"award-number":["No. DST\/INSPIRE Fellowship\/2014\/51"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Evaluation of the toxic effects of a widely used synthetic pyrethroid, deltamethrin (DM), was carried out in this study. This pesticide is preferred for pest control because of its low environmental persistence and toxicity. We investigated the expression pattern of four genes, namely, you ( you), yot ( you-too), momo ( mom) and ubo ( u-boot) during early development of zebrafish, that is, from 12 hpf to 48 hpf stages. These stages are selected as most of the important developmental aspects take place during this period. All four genes are known to play a vital role in development of notochord and somites. To understand the effect of DM on development, embryos of 4 hpf stage were exposed to two concentrations (100 and 200 \u00b5g\/L) of DM, and observations were made at 12, 24 and 48 hpf stages. Our earlier studies have shown phenotypic abnormalities such as notochord bending, tail deformation, yolk sac and pericardial edema, lightening of body and eye pigmentation and interfered in somite patterning, during these stages of development. Understanding the relationship of phenotypic abnormalities with these four genes has been our primary objective. These four genes were analyzed by Reverse transcription (RT)-polymerase chain reaction and intensity of the bands has shown induction in their expression after exposure to the toxicant. In spite of the expression of genes, it was noticed that DM caused abnormalities. It can be said from the results that translational pathway could have been affected.<\/jats:p>","DOI":"10.1177\/0748233718807046","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T22:34:17Z","timestamp":1544049257000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Zebrafish embryos exposed to deltamethrin exhibit abnormalities despite induced expression of related genes (\n                    <i>you, you-too, momo and u-boot<\/i>\n                    )"],"prefix":"10.1177","volume":"35","author":[{"given":"Kuder Reshma","family":"Shabnam","sequence":"first","affiliation":[{"name":"Department of Zoology, Sri Krishnadevaraya University, Anantapuram, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharmapuri","family":"Gangappa","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, School of life Sciences, University of Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-4750","authenticated-orcid":false,"given":"Gundala Harold","family":"Philip","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, School of life Sciences, University of Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"issue":"2","key":"bibr1-0748233718807046","first-page":"41","volume":"9","author":"Abbas OS","year":"2016","journal-title":"Veterinary Science"},{"key":"bibr2-0748233718807046","first-page":"77","volume":"2","author":"Bowman AF","year":"2006","journal-title":"An Overview of Image"},{"key":"bibr3-0748233718807046","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1242\/dev.123.1.179","volume":"123","author":"Brand M","year":"1996","journal-title":"Development"},{"key":"bibr4-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00123-0"},{"key":"bibr5-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8034189"},{"key":"bibr6-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.23.040183.002213"},{"key":"bibr7-0748233718807046","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1242\/dev.122.11.3371","volume":"122","author":"Devoto SH","year":"1996","journal-title":"Development"},{"issue":"5","key":"bibr8-0748233718807046","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1016\/S0021-9258(18)49968-1","volume":"266","author":"Donaldson RW","year":"1991","journal-title":"Journal of Biological Chemistry"},{"key":"bibr9-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(94)90091-4"},{"key":"bibr10-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1039\/cs9780700473"},{"key":"bibr11-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1038\/248710a0"},{"key":"bibr12-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.23.010178.002303"},{"issue":"5","key":"bibr13-0748233718807046","first-page":"1761","volume":"49","author":"Farooqui MA","year":"2017","journal-title":"Pakistan Journal of Zoology"},{"key":"bibr14-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90314-S"},{"key":"bibr15-0748233718807046","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1242\/dev.123.1.153","volume":"123","author":"Fredericus JM","year":"1996","journal-title":"Development"},{"key":"bibr16-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2007.01.005"},{"key":"bibr17-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80087-X"},{"key":"bibr18-0748233718807046","volume-title":"Chemistry of Plant Protection 4: Synthetic Pyrethroid Insecticides: Structures and Properties","author":"Haug G","year":"1990"},{"key":"bibr19-0748233718807046","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14080833"},{"key":"bibr20-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(02)00854-8"},{"key":"bibr21-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1584\/jpestics.3.43"},{"key":"bibr22-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1740"},{"key":"bibr51-0748233718807046","author":"Kidd H","year":"1991","journal-title":"Royal Society of Chemistry Information Services"},{"key":"bibr23-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.06.016"},{"key":"bibr24-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"bibr25-0748233718807046","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvh144"},{"key":"bibr26-0748233718807046","unstructured":"Nalini D (2012) Effect of synthetic pyrethroid deltamethrin on hatching and development in zebrafish, Danio rerio. 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