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Forty-eight 60-day-old Institute of Cancer Research (ICR) mice were administered DBP by gavage once a day for 10 days. The mice were divided into three groups of 16 mice each: the high-dose group was administered 500 mg\/kg body weight (BW) DBP; the low-dose group was administered 50 mg\/kg BW; and the control group was not administered DBP. Significant increases in the uterine index, ovary index, and testicular index were observed in the DBP-exposed groups compared to those in the control group. Villus height and V\/ C ratio significantly increased ( p &lt; 0.05) in the duodenum and decreased ( p &lt; 0.05) in the jejunum after the administration of DBP. The goblet cell number decreased in both the duodenum and the jejunum of mice exposed to DBP ( p &lt; 0.05) compared to the number in the control group mice. Damage to the structure of the small intestine was accompanied by a marked increase in HSP27 expression and a decrease in the expression of HSP70 and HSP90 in both high-dose and low-dose groups. These results indicate that elevated HSP27 levels in the duodenum and jejunum may be important markers for acute DBP exposure and that HSP27 may act as a protective protein involved in intestinal mucosa repair.<\/jats:p>","DOI":"10.1177\/0748233718807303","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T23:02:05Z","timestamp":1542668525000},"page":"20-31","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Short-term toxicity of dibutyl phthalate to mice intestinal tissue"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1426-8051","authenticated-orcid":false,"given":"Jimian","family":"Yu","sequence":"first","affiliation":[{"name":"Ningbo College of Health Sciences, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biological 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