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Animals were dermally exposed to soil contaminated with SEO for 120 consecutive days and compared with rats exposed to uncontaminated soil (negative control). Heavy metal (lead (Pb), nickel (Ni), zinc, and cadmium (Cd)) accumulations, hematology, biochemical (aspartate aminotransferase (AST), alanine aminotransferase, alkaline phosphatase (ALP), urea, and creatinine) parameters, sperm morphology, and histopathology (liver, kidney, lungs, brain, skin, and testis) were evaluated as end points. Results revealed that the heavy metals in SEO-contaminated soil are far greater than the World Health Organisation permissible limits, with significant ( p &lt; 0.05) increases of Pb and Ni present in the brain, and Pb and Cd in the serum compared with the uncontaminated soil for the negative control. Only significant ( p &lt; 0.05) values were observed in the lymphocytes, activities of AST and ALP, and sperm abnormalities of the exposed rats compared with those used for the negative control. Histopathological changes were not evident in the brain but lesions were observed in the liver, kidney, lungs, skin, and testis of the exposed rats. Results herein suggest that the constituents of SEO may elicit harmful physiological changes to humans who are directly exposed to them.<\/jats:p>","DOI":"10.1177\/0748233720968466","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:05:27Z","timestamp":1603843527000},"page":"979-994","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of long-term dermal exposure to soil contaminated with spent engine oil in male Wistar rats: An experimental approach"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6142-1541","authenticated-orcid":false,"given":"Grace E","family":"Obiyo","sequence":"first","affiliation":[{"name":"Ecology and Environmental Unit, Department of Zoology, University of Ibadan, Oyo State, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6685-6029","authenticated-orcid":false,"given":"Opeoluwa M","family":"Ogunsuyi","sequence":"additional","affiliation":[{"name":"Cell Biology and Genetics Unit, University of Ibadan, Oyo State, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeyi","family":"Akindele O","sequence":"additional","affiliation":[{"name":"Animal Physiology Unit, Department of Zoology, University of Ibadan, Ibadan, Oyo State, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"bibr1-0748233720968466","volume-title":"Toxicological Profile for Lead","author":"Abadin H","year":"2007"},{"key":"bibr2-0748233720968466","doi-asserted-by":"publisher","DOI":"10.14419\/ijet.v7i3.11.15942"},{"key":"bibr3-0748233720968466","volume-title":"Toxicological Profile for mineral base crankcase oil","author":"Agency for Toxic Substances and Disease Registry (ATSDR)","year":"1997"},{"key":"bibr4-0748233720968466","volume-title":"Toxicological Profile for Cadmium","author":"Agency for Toxic Substances and Disease Registry (ATSDR)","year":"2012"},{"key":"bibr5-0748233720968466","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR) (2019) Substance Priority List. 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