{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:35:01Z","timestamp":1777923301669,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    HFC-43-10mee is a volatile liquid at room temperature and used as a cleaning agent, aerosol, etc. HFC-43-10mee has low acute inhalation toxicity; 4-hour LC\n                    <jats:sub>50<\/jats:sub>\n                    in rats of approximately 11,000 ppm. The compound was not a skin or eye irritant and was not a skin sensitizer. A cardiac sensitization response was not observed at 5000 ppm. Inhalation exposure resulted in neurotoxicity consisting of tremors, convulsions, jerking, ataxia, abnormal gait, etc. at exposure concentrations of 2000 ppm and above. Within approximately 30 min of exposure the clinical signs appeared and resolved within 1\u20132 h during exposure; the rats appeared to adapt such that these clinical signs were no longer observed. The neurotoxicity observed was considered an acute response to HFC-43-10mee. In a 90-day study, rats exposed to 2000 ppm resulted in sporadic clinical signs of neurotoxicity. At 3500 ppm, the clinical signs were evident on most exposure days although as the study progressed the apparent incidence declined likely reflecting adaptation. The NOAEL was 500 ppm. Based on the occurrence of the clinical signs in this and other studies, an acute threshold for neurotoxicity was evident at approximately 2000 ppm and above. No developmental or reproductive toxicity were evident at 2000 ppm, although clinical signs of neurotoxicity occurred in maternal or parental rats at 2000 ppm. No effects on offspring were observed. HFC-43-10mee was not genotoxic in vitro or in vivo. Based on the data, the 8-h TWA WEEL value is 225 ppm (2320 mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    ). The 15-min STEL is 700 ppm (7217 mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    ).\n                  <\/jats:p>","DOI":"10.1177\/07482337211019860","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T03:33:18Z","timestamp":1626147198000},"page":"441-450","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["1,1,1,2,3,4,4,5,5,5-Decafluoropentane (HFC-4310mee)"],"prefix":"10.1177","volume":"37","member":"179","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"bibr1-07482337211019860","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.12.007"},{"key":"bibr2-07482337211019860","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2014.07.005"},{"key":"bibr3-07482337211019860","doi-asserted-by":"publisher","DOI":"10.1016\/S0273-2300(03)00072-2"},{"key":"bibr4-07482337211019860","volume-title":"Two-week inhalation toxicity study with HFC-43-10mee in male rats","author":"DuPont","year":"1992"},{"key":"bibr5-07482337211019860","volume-title":"Primary Eye Irritation Study in Rabbits","author":"DuPont","year":"1993"},{"key":"bibr6-07482337211019860","volume-title":"Acute Dermal Irritation\/corrosion Study in Rabbits","author":"DuPont","year":"1993"},{"key":"bibr7-07482337211019860","volume-title":"Inhalation Approximate Lethal Concentration (ALC) of H-18780\/H-18891 in Rats","author":"DuPont","year":"1993"},{"key":"bibr8-07482337211019860","volume-title":"HFC-43-10mee: Assessment of Cardiac Sensitization Potential in Dogs","author":"DuPont","year":"1994"},{"key":"bibr9-07482337211019860","volume-title":"Subchronic Inhalation Toxicity: 90-Day Study with H-20255 Inhalation Study in Rats","author":"DuPont","year":"1994"},{"key":"bibr10-07482337211019860","volume-title":"Developmental Toxicity Study of H-20255 in Rats","author":"DuPont","year":"1994"},{"key":"bibr11-07482337211019860","volume-title":"Mutagenicity Testing of H-20255 in the Salmonella typhimurium and Escherichia coli Plate Incorporation Assay","author":"DuPont","year":"1994"},{"key":"bibr12-07482337211019860","volume-title":"Rat Bone Marrow Micronucleus Assay of H-20255 by Inhalation","author":"DuPont","year":"1994"},{"key":"bibr13-07482337211019860","volume-title":"1-Octanol\/Water Partition Coefficient Test of HFC-43-10mee","author":"DuPont","year":"1995"},{"key":"bibr14-07482337211019860","volume-title":"Acute oral toxicity study in male and female rats","author":"DuPont","year":"1995"},{"key":"bibr15-07482337211019860","volume-title":"Approximate Lethal Dose (ALD) by Skin Absorption in Rabbits","author":"DuPont","year":"1995"},{"key":"bibr16-07482337211019860","volume-title":"Delayed contact hypersensitivity test (Buehler Method) in guinea pigs","author":"DuPont","year":"1995"},{"key":"bibr17-07482337211019860","volume-title":"Neurotoxicity Study of H# 20798 in Rats","author":"DuPont","year":"1995"},{"key":"bibr18-07482337211019860","volume-title":"In Vitro Evaluation of H-20798 for Chromosome Aberrations in Human Lymphocytes","author":"DuPont","year":"1995"},{"key":"bibr19-07482337211019860","volume-title":"Physico-chemical properties of Vertrel\u00ae","author":"DuPont","year":"1996"},{"key":"bibr20-07482337211019860","volume-title":"Acute inhalation toxicity study of HFC-4310 in albino rats","author":"DuPont","year":"1996"},{"key":"bibr21-07482337211019860","volume-title":"Comparative Neurotoxicity Study of HFC-43-10mee and HFC-43-10mee\/DCE 50\/50 Blend in Rats","author":"DuPont","year":"1997"},{"key":"bibr22-07482337211019860","volume-title":"H-27450: One-Generation Reproduction Study in Rats","author":"DuPont","year":"2007"},{"key":"bibr23-07482337211019860","volume-title":"H-28502: In Vitro Mammalian Cell Gene Mutation Test (L5178Y\/TK+\/\u2212 Mouse Lymphoma Assay)","author":"DuPont","year":"2008"},{"key":"bibr24-07482337211019860","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.11.028"},{"key":"bibr25-07482337211019860","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(85)90049-1"},{"key":"bibr26-07482337211019860","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S50371"},{"key":"bibr27-07482337211019860","first-page":"511","volume":"22","author":"Loizou GD","year":"1994","journal-title":"Drug Metabolism and Disposition"},{"key":"bibr28-07482337211019860","first-page":"875","volume":"23","author":"Loizou GD","year":"1995","journal-title":"Drug Metabolism and Disposition"},{"key":"bibr29-07482337211019860","volume-title":"Assessment Report HFC-43-10mee","author":"National Industrial Chemicals Notification and Assessment Scheme (NICNAS)","year":"1999"},{"key":"bibr30-07482337211019860","doi-asserted-by":"publisher","DOI":"10.3109\/00498259409043287"},{"key":"bibr31-07482337211019860","volume-title":"Fluorides. 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