{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:54:05Z","timestamp":1793055245925,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>\n                    Sulfur dioxide (SO\n                    <jats:sub>2<\/jats:sub>\n                    ) is a common air pollutant that can exacerbate asthmatic airway inflammation. The mechanisms underlying these effects are not yet fully understood. In this study, we investigated the effects of SO\n                    <jats:sub>2<\/jats:sub>\n                    exposure (10\u00a0mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    ) on asthmatic airway inflammation in ovalbumin-induced asthmatic mice. Our results showed that SO\n                    <jats:sub>2<\/jats:sub>\n                    exposure alone induced slight airway injury, decreased superoxide dismutase activity, and increased nuclear factor-\u03baB (NF-\u03baB) expression in the lungs of mice. Moreover, SO\n                    <jats:sub>2<\/jats:sub>\n                    exposure in asthmatic mice induced marked pathological damage, significantly increased the counts of inflammatory cells (e.g., macrophages, lymphocytes, and eosinophils) in bronchoalveolar lavage fluid, and significantly enhanced malondialdehyde and glutathione levels in the lungs. Moreover, the expression of toll-like receptor 4 (TLR4), NF-\u03baB, pro-inflammatory cytokines (e.g., tumor necrosis factor \u03b1 and interleukin-6), and type II T-helper cell (Th2) cytokines was found to be elevated in the mice exposed to SO\n                    <jats:sub>2<\/jats:sub>\n                    and ovalbumin compared to those exposed to ovalbumin alone. These results suggest that SO\n                    <jats:sub>2<\/jats:sub>\n                    amplifies Th2-mediated inflammatory responses, which involve reactive oxygen species and TLR4\/NF-\u03baB pathway activation; these can further enhance Th2 cytokine expression and eosinophilic inflammation. Thus, our findings provide important evidence to understand a potential mechanism through which SO\n                    <jats:sub>2<\/jats:sub>\n                    may exacerbate airway asthmatic inflammation.\n                  <\/jats:p>","DOI":"10.1177\/07482337211033136","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T06:40:17Z","timestamp":1630046417000},"page":"564-572","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Sulfur dioxide-induced exacerbation of airway inflammation via reactive oxygen species production and the toll-like receptor 4\/nuclear factor-\u03baB pathway in asthmatic mice"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0232-4001","authenticated-orcid":false,"given":"Lingxiu","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Life Science, Shanxi University, Taiyuan, China"},{"name":"College of Environment and Resource Sciences, Shanxi University, Taiyuan, China"},{"name":"Department of Biology, Xinzhou Teachers University, Xinzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilan","family":"Yi","sequence":"additional","affiliation":[{"name":"School of Life Science, Shanxi University, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Sang","sequence":"additional","affiliation":[{"name":"College of Environment and Resource Sciences, Shanxi University, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"bibr1-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.047"},{"key":"bibr2-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067115"},{"key":"bibr3-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36130"},{"key":"bibr4-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-114"},{"key":"bibr5-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440507"},{"key":"bibr6-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03053.x"},{"key":"bibr7-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.127436"},{"key":"bibr8-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/218957"},{"key":"bibr9-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201102095"},{"key":"bibr10-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60617-6"},{"key":"bibr11-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.278.3.L492"},{"key":"bibr12-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.037"},{"key":"bibr13-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11471-y"},{"key":"bibr14-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.03.014"},{"key":"bibr15-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3049"},{"key":"bibr16-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2016.05.014"},{"key":"bibr17-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.04.065"},{"key":"bibr18-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1177\/1091581816682225"},{"key":"bibr19-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2019.1590591"},{"key":"bibr20-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.12.020"},{"key":"bibr21-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1080\/08958370304476"},{"key":"bibr22-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(03)00045-8"},{"key":"bibr23-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.24"},{"key":"bibr24-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03854.x"},{"key":"bibr25-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174050"},{"key":"bibr26-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.09.033"},{"key":"bibr27-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1038\/nri2735"},{"key":"bibr28-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2019.1611844"},{"key":"bibr29-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2012.09.010"},{"key":"bibr30-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2020.1871374"},{"key":"bibr31-07482337211033136","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2016.08.018"},{"key":"bibr32-07482337211033136","unstructured":"World Health Organization (2020a) Asthma fact sheet. 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