{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:34:15Z","timestamp":1777923255853,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>The mechanism of kidney injury in occupational medicamentosa-like dermatitis due to trichloroethylene exposure is not well understood. This study aimed to investigate the role of endothelin-1 (ET-1)\/vascular endothelial-derived growth factor-A (VEGF-A) in trichloroethylene (TCE)-induced renal injury. Forty BALB\/c female mice were used in this study to build the TCE-sensitization mouse model. Transmission electron microscopic observation, histological examination, periodic acid-Schiff staining, serum urea nitrogen, creatinine, and urinary total protein levels were used to reflect renal injury. Glypican1, syndecan1, ET-1 and VEGF-A protein levels were measured by western blot. Serum ET-1 level was also measured. Tumor necrosis factor alpha (TNF-\u03b1) and vascular cell adhesion molecule-1 (VCAM-1) were detected by immunohistochemistry. The results showed that TCE-sensitized mouse kidneys were damaged and accompanied by increased serum ET-1. After treatment with CGS 35066, the inhibitor of endothelin converting enzyme-1 (ECE-1), kidney ET-1, TNF-\u03b1 and VCAM-1 levels decreased, and renal function improved in TCE+CGS 35066\u2013sensitized positive mice. In addition, kidney VEGF-A, glomerular endothelial cell glypican1 and syndecan1 levels increased, and endothelial cell damage was alleviated after treatment with CGS 35066. The results suggest that inhibiting ECE-1 could alleviate glomerular endothelial cell injury by inhibiting ET-1 expression, thus promoting endothelial cell repair by upregulating VEGF-A.<\/jats:p>","DOI":"10.1177\/07482337221092507","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T01:03:15Z","timestamp":1650848595000},"page":"287-298","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Endothelin-1 down-regulated vascular endothelial growth factor A is involved in trichloroethene-induced kidney injury"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-8734","authenticated-orcid":false,"given":"Haibo","family":"Xie","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Anhui Medical University"},{"name":"Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuesong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiale","family":"Peng","sequence":"additional","affiliation":[{"name":"Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1782-1801","authenticated-orcid":false,"given":"Lihua","family":"Deng","sequence":"additional","affiliation":[{"name":"Shenzhen Prevention and Treatment Center for Occupational Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education"},{"name":"Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qixing","family":"Zhu","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Anhui Medical University"},{"name":"Ministry of Education"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,24]]},"reference":[{"issue":"1","key":"e_1_3_4_2_1","first-page":"45","article-title":"Study on neurobehavioral function of workers exposed to trichloroethylene","volume":"17","author":"Ai BL","year":"2001","unstructured":"Ai BL, Liu YM, Xiao YM, et al. 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