{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:35:55Z","timestamp":1777923355278,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>The WEEL for triethylenetetramine (TETA; CAS No. 112-24-3) was originally established in 1991 and updated in 1998 and 2009. Recent literature searches to identify new toxicity information were performed in 2016 and January 2021. No new studies or data relevant to the WEEL were identified. TETA is used in manufacturing; the hydrochloride salt of TETA is used as a copper-chelating drug in the treatment of Wilson\u2019s disease. TETA is severely irritating to the skin and eyes and produces skin sensitization; however, it is of low to moderate acute toxicity via the oral and dermal routes of exposure. In subchronic studies, signs of toxicity included multi-organ effects (lung, liver, and spleen) in mice, but not rats. TETA was genotoxic\/mutagenic in short-term in vitro assays but not in in vivo assays. No data on reproductive toxicity were available. Embryo\/fetal toxicity occurred at maternally toxic doses and was associated with copper deficiency. In humans, the use of TETA\u00b72HCl for treatment of Wilson\u2019s disease during pregnancy resulted in no miscarriages or fetal abnormalities. No evidence of carcinogenicity was noted in a lifetime dermal study in mice. Based on a subchronic drinking water study in mice, 600 ppm (95\u00a0mg\/kg-day) was determined to be the no-observed-adverse-effect level (NOAEL) and the point of departure (POD). This NOAEL was converted to an equivalent inhalation concentration by adjusting for respiratory rate, interindividual variability, and uncertainty. The resulting 8-h time-weighted average WEEL value of 1 ppm is expected to provide a significant margin of safety against any potential adverse health effects in workers exposed to airborne TETA.<\/jats:p>","DOI":"10.1177\/07482337231161152","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T01:21:37Z","timestamp":1679361697000},"page":"183-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Triethylenetetramine (TETA)"],"prefix":"10.1177","volume":"39","author":[{"name":"Workplace Environmental Exposure Level (WEEL) Committee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Occupational Alliance for Risk Science (OARS)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Toxicology Excellence for Risk Assessment (TERA)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"bibr1-07482337231161152","volume-title":"Diethylenetriamine (1974-75 Results) - Range Finding Toxicity and 7-day Dietary Inclusion Studies by RC Myers, CS Weil and EF Cox","author":"Chemical Hygiene Fellowship","year":"1976"},{"key":"bibr2-07482337231161152","first-page":"203","volume":"2","author":"Cohen NL","year":"1983","journal-title":"Drug-Nutrient Interactions"},{"key":"bibr3-07482337231161152","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(87)90187-4"},{"key":"bibr4-07482337231161152","unstructured":"Dobryszycka W, Warwas M, Woyton A, et al. (1974) L\u2019effet des pollutions industrielles sur la grossesse. Le Pharmacien Biologiste 9(98): 55\u201359. 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