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Twenty-four (24) male albino rats (75 \u00b1 16\u00a0g) were randomized into three experimental groups ( N = 8). The control group: received normal saline, PET group: exposed to PET 6\u00a0h daily by inhalation in an exposure chamber and PET + 200\u00a0mg ASCB\/kg body weight group: exposed to PET 6\u00a0h daily by inhalation and administered ASCB per os. Treatment of ASCB and PET exposure was done thrice and five times weekly for a period of 10\u00a0weeks respectively. ASCB co-treatment prevented PET-induced increases in the oxidative stress markers (glutathione, glutathione S-transferase, superoxide dismutase, catalase, hydrogen peroxide generation, nitric oxide, and lipid peroxidation) and serum testosterone concentration ( p &lt; .05). Sperm quality was low and those with damaged heads and tails increased alongside histological injuries in the PET-exposed rats, which were also minimized with ASCB administration. ASCB protected against PET-induced oxidative stress, sperm, and testis damage in rats.<\/jats:p>","DOI":"10.1177\/07482337241245154","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T05:07:10Z","timestamp":1712725630000},"page":"323-336","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ascorbic acid attenuates gasoline-induced testicular toxicity, sperm quality deterioration, and testosterone imbalance in rats"],"prefix":"10.1177","volume":"40","author":[{"given":"Ogechukwu E","family":"Ezim","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Port Harcourt, Choba, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Nyeche","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Port Harcourt, Choba, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisom E","family":"Nebeolisa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Port Harcourt, Choba, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuka D","family":"Belonwu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Port Harcourt, Choba, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-2689","authenticated-orcid":false,"given":"Sunny O","family":"Abarikwu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Port Harcourt, Choba, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"bibr1-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-009-9371-2"},{"key":"bibr2-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21449"},{"key":"bibr3-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-016-0622-5"},{"key":"bibr4-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1536-2"},{"key":"bibr5-07482337241245154","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_81_20"},{"issue":"1","key":"bibr6-07482337241245154","first-page":"23","volume":"22","author":"Abubakar MB","year":"2015","journal-title":"Malaysian Journal of Medical Sciences"},{"key":"bibr7-07482337241245154","doi-asserted-by":"publisher","DOI":"10.29252\/cjhr.5.2.34"},{"key":"bibr8-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2020.01.017"},{"key":"bibr9-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-017-0025-3"},{"issue":"5","key":"bibr10-07482337241245154","first-page":"IE01","volume":"11","author":"Asadi N","year":"2017","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"bibr11-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-13-17"},{"key":"bibr12-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/30.3.234"},{"key":"bibr13-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(55)02300-8"},{"issue":"3","key":"bibr14-07482337241245154","first-page":"232","volume":"31","author":"Chinoy NJ","year":"1986","journal-title":"International Journal of Fertility"},{"key":"bibr15-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801238-3.01973-5"},{"issue":"3","key":"bibr16-07482337241245154","first-page":"201","volume":"4","author":"Das UB","year":"2002","journal-title":"Asian Journal of Andrology"},{"key":"bibr17-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.12.8940355"},{"key":"bibr18-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1177\/2325967118804544"},{"key":"bibr19-07482337241245154","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2020.552969"},{"key":"bibr20-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1111\/and.14578"},{"key":"bibr21-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-100"},{"key":"bibr22-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12866"},{"key":"bibr23-07482337241245154","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42083-8"},{"key":"bibr24-07482337241245154","doi-asserted-by":"publisher","DOI":"10.25122\/jml-2019-0107"},{"issue":"2","key":"bibr25-07482337241245154","first-page":"29","volume":"6","author":"Hassan AM","year":"2008","journal-title":"Journal of. 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