{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T18:16:12Z","timestamp":1778436972194,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073566"],"award-info":[{"award-number":["82073566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073578"],"award-info":[{"award-number":["82073578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Program for Excellent Young Talents in College and University of Anhui Province","award":["gxyq2019014"],"award-info":[{"award-number":["gxyq2019014"]}]},{"name":"The Anhui Medical University Clinical Pharmacology and Pharmacology Co-construction Project"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Previous epidemiologic research has shown that phthalate exposure in pregnant women is related to adverse birth outcomes in a sex-specific manner. However, the biological mechanism of phthalate exposure that causes these birth outcomes remains poorly defined. In this research, we investigated the association between phthalate exposure and placental oxidative stress in a large population-based cohort study, aiming to initially explore the relationship between phthalate exposure and gene expression in placental oxidative stress in a sex-specific manner. Quantitative PCR was performed to measure the expression of placental inflammatory mRNAs (HO-1, HIF1\u03b1, and GRP78) in 2469 placentae. The multiple linear regression models were used to investigate the associations between mRNA and urinary phthalate monoesters. Phthalate metabolites monomethyl phthalate (MMP) and mono-n-butyl phthalate (MBP) were positively correlated with higher HIF1\u03b1 expression in placentae of male fetuses ( p &lt; .05). Mono-benzyl phthalate (MBzP) increased the expression of HO-1, HIF1\u03b1, and GRP78 in placentae of male fetuses, and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) up-regulated the expression of HIF1\u03b1 and GRP78. Additionally, mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) was negatively correlated with HO-1, HIF1\u03b1, and GRP78 in placentae of female fetuses. Maternal phthalate exposure was associated with oxidative stress variations in placental tissues. The associations were closer in the placentas of male fetuses than in that of female ones. The placenta oxidative stress is worth further investigation as a potential mediator of maternal exposure-induced disease risk in children.<\/jats:p>","DOI":"10.1177\/07482337241245453","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:59:26Z","timestamp":1712624366000},"page":"312-322","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Gender associations between phthalate exposure and biomarkers of oxidative stress: A prospective cohort study"],"prefix":"10.1177","volume":"40","author":[{"given":"Jian-Qing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China"},{"name":"MOE Key Laboratory of Population Health across Life Cycle, Hefei, China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, 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