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We reviewed the current state of the science regarding the factors influencing mesotheliogenic potency of cleavage fragments, with emphasis on those that may co-occur in talc deposits, including dimensional and structural characteristics, animal toxicology, and the most well-studied cohort exposed to talc-associated cleavage fragments. Based on our review, multiple lines of scientific evidence demonstrate that inhaled cleavage fragments associated with talc do not pose a mesothelioma hazard.<\/jats:p>","DOI":"10.1177\/07482337241246924","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:38:33Z","timestamp":1713177513000},"page":"398-424","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["A review of the mesotheliogenic potency of cleavage fragments found in talc"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0950-9711","authenticated-orcid":false,"given":"E","family":"Miller","sequence":"first","affiliation":[{"name":"Benchmark Risk Group, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8639-2129","authenticated-orcid":false,"given":"EM","family":"Beckett","sequence":"additional","affiliation":[{"name":"Benchmark Risk Group, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3955-3894","authenticated-orcid":false,"given":"D","family":"Cheatham","sequence":"additional","affiliation":[{"name":"Benchmark Risk Group, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-7462","authenticated-orcid":false,"given":"CE","family":"Comerford","sequence":"additional","affiliation":[{"name":"Benchmark Risk Group, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5256-6143","authenticated-orcid":false,"given":"RC","family":"Lewis","sequence":"additional","affiliation":[{"name":"Benchmark Risk Group, Oakland, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6838-1563","authenticated-orcid":false,"given":"C","family":"Krevanko","sequence":"additional","affiliation":[{"name":"Benchmark Risk Group, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4220-9675","authenticated-orcid":false,"given":"N","family":"Mandava","sequence":"additional","affiliation":[{"name":"Benchmark Risk Group, Denver, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7722-9901","authenticated-orcid":false,"given":"JS","family":"Pierce","sequence":"additional","affiliation":[{"name":"Benchmark Risk Group, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"bibr1-07482337241246924","unstructured":"Abraham J (1990) Non-Commercial Amphibole Asbestos Fibers and Cleavage Fragments in Lung Tissues of New York State Talc Miners with Asbestosis and Talcosis. 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