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Toward this aim, the rats ( n = 28) were given a vehicle (control) or BPS at 3 different doses, comprising 20, 100, and 500\u00a0mg\/kg of body weight (bw) via oral gavage for 28\u00a0days. According to the results, BPS led to numerous histopathological changes in the thyroid tissue. The average proliferation index values among the thyroid follicular cells (TFCs) displayed increases in all of the BPS groups, and significant differences were observed in the BPS-20 and BPS-100 groups. The average apoptotic index values in the TFCs were increased significantly in the BPS-500 group. The serum thyroid-stimulating hormone and serum free thyroxine levels did not show significant changes after exposure to BPS; however, the serum free triiodothyronine levels displayed significant decreases in all 3 of the BPS groups. BPS was determined to cause significant increases in the antioxidant enzyme activities of catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, as well as a significantly decreased content of reduced glutathione. The malondialdehyde level in the thyroid tissue was elevated significantly in the BPS-500 group. The data obtained herein revealed that BPS has thyroid-disrupting potential based on structural changes, follicle cell responses, and biochemical alterations including a decreased serum free triiodothyronine level and increased oxidative stress.<\/jats:p>","DOI":"10.1177\/07482337241267247","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T22:53:47Z","timestamp":1723589627000},"page":"559-580","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Thyroid-disrupting effects of bisphenol S in male Wistar albino rats: Histopathological lesions, follicle cell proliferation and apoptosis, and biochemical changes"],"prefix":"10.1177","volume":"40","author":[{"given":"M\u00fc\u015ferref","family":"Bostanc\u0131","sequence":"first","affiliation":[{"name":"Department of Biology, Institute of Natural and Applied Sciences, Van Yuzuncu Yil University, Tu\u015fba, 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