{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:35:59Z","timestamp":1777923359719,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Arsenic and its inorganic compounds affect numerous organs and systemic functions, such as the nervous and hematopoietic systems, liver, kidneys, and skin. Despite a large number of studies on arsenic toxicity, rare reports have investigated the leukopenia incidence in workers exposed to arsenic. In workplaces, the main source of workers\u2019 exposure is the contaminated air by the inorganic arsenic in mines, arsenic or copper smelter industries, and chemical factories. Erythropoiesis inhibition is one of the arsenic effects and it is related to regulatory factor GATA-1. This factor is necessary for the normal differentiation of early erythroid progenitors. JAK-STAT is an important intracellular signal transduction pathway responsible for the mediating normal functions of several cytokines related to cell proliferation and hematopoietic systems development and regulation. Arsenic inactivates JAK-STAT by inhibiting JAK tyrosine kinase and using the IFN\u03b3 pathway. The intravascular hemolysis starts after the absorption phase when arsenic binds to the globin of hemoglobin in erythrocytes and is transported into the body, which increases the oxidation of sulfhydryl groups in hemoglobin. So, this article intends to highlight the potential leukopenia risk via inhalation for workers exposed to arsenic and suggests a possible mechanism for this leukopenia through the JAK-signal transducer and activator of transcription (STAT) pathway inhibition.<\/jats:p>","DOI":"10.1177\/07482337241277261","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T11:29:00Z","timestamp":1725276540000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Occupational exposure to arsenic and leukopenia risk: Toxicological alert"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-1044","authenticated-orcid":false,"given":"Nadielle Silva","family":"Bidu","sequence":"first","affiliation":[{"name":"Pharmacy Postgraduate Program, Faculty of Pharmacy, Federal University of Bahia\/UFBA, Salvador, Brazil"},{"name":"Clinical Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia\/UFBA, Salvador, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6123-2505","authenticated-orcid":false,"given":"Diogo Sousa","family":"Lemos","sequence":"additional","affiliation":[{"name":"Undersecretary of Safety and Health at Work of the Brazil Federal District, Distrito Federal, Health Department, Brasilia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-2978","authenticated-orcid":false,"given":"Bruno Jos\u00e9 Dum\u00eat","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Clinical Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia\/UFBA, Salvador, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"bibr1-07482337241277261","unstructured":"ATSDR (2023) Arsenic toxicity what are the standards and regulation for arsenic exposure? 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