{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:58:57Z","timestamp":1782230337052,"version":"3.54.5"},"reference-count":58,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["22879"],"award-info":[{"award-number":["22879"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    Acrylamide (Acr) poses reproductive toxicity risks to humans due to its ability to penetrate cell membranes and disrupt cellular balance. Taurine (Tau), a sulfur-containing amino acid with cell membrane stabilization and antioxidant properties, may mitigate these effects. This study examined how Tau can protect against oxidative stress and apoptosis induced by Acr in mouse ovarian tissue. Forty adult healthy mice, aged 6\u20138\u00a0weeks, were randomly assigned to four groups including the controls (received normal saline orally), Acr (50\u00a0mg\/kg\/day Acr orally), Acr + Tau75 (Acr and 75\u00a0mg\/kg\/day Tau), and Acr + Tau150 (Acr and 150\u00a0mg\/kg\/day Tau). Treatments were administered for 35\u00a0days, followed by assessments of stress markers and apoptosis via immunofluorescence and TUNEL assays. Both doses of Tau significantly increased the gene and protein expression levels of stress response enzymes, including\n                    <jats:italic>Gpx1<\/jats:italic>\n                    ,\n                    <jats:italic>Sod1<\/jats:italic>\n                    , and\n                    <jats:italic>Cat<\/jats:italic>\n                    . Moreover, Tau significantly decreased the gene expression levels of apoptotic markers\n                    <jats:italic>Caspase3<\/jats:italic>\n                    and\n                    <jats:italic>B<\/jats:italic>\n                    <jats:italic>ax<\/jats:italic>\n                    , while upregulating the antiapoptotic gene\n                    <jats:italic>Bcl2l2<\/jats:italic>\n                    . The TUNEL assay revealed the preventive properties of Tau against Acr-induced apoptosis in the ovaries. The current findings suggest the promising properties of Tau in the prevention of Acr-induced oxidative stress and apoptosis in mouse ovarian tissue. Therefore, Tau could play a protective role against Acr-induced reproductive toxicity in females, meriting further research into its potential applications.\n                  <\/jats:p>","DOI":"10.1177\/07482337251335541","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T07:29:06Z","timestamp":1745047746000},"page":"282-293","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Taurine alleviated acrylamide-induced ovarian toxicity via suppression of oxidative stress and apoptosis in mice"],"prefix":"10.1177","volume":"41","author":[{"given":"Zahra","family":"Khodabandeh","sequence":"first","affiliation":[{"name":"Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Alaee","sequence":"additional","affiliation":[{"name":"Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1741-503X","authenticated-orcid":false,"given":"Mohammad","family":"Samare-Najaf","sequence":"additional","affiliation":[{"name":"Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-6262","authenticated-orcid":false,"given":"Elham","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Zanjan Metabolic Diseases Research Center, Health and Metabolic Diseases Research Institute, Zanjan University of Medical Sciences, Zanjan, Iran"},{"name":"Department of Obstetrics and Gynecology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahintaj","family":"Dara","sequence":"additional","affiliation":[{"name":"Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Shokri","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Shirazi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, Medicine and Health, UNSW Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2023.00257"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23945"},{"issue":"4","key":"e_1_3_5_4_1","first-page":"72","article-title":"Air pollution and infertility\u2013a letter to editor","volume":"6","author":"Alaee S","year":"2018","unstructured":"Alaee S (2018) Air pollution and infertility\u2013a letter to editor. 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