{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:20:49Z","timestamp":1784805649120,"version":"3.55.0"},"reference-count":61,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"DR. SHASHI BALA","award":["Indian Council of Medical Research, New Delhi, India"],"award-info":[{"award-number":["Indian Council of Medical Research, New Delhi, India"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    Radiation exposures, whether planned or unexpected, can have harmful consequences on biological systems. To avoid these radiotoxic consequences, a variety of natural and synthetic radioprotectors are given prior to radiation exposure. The present study aimed to investigate the radioprotective potential of\n                    <jats:italic toggle=\"yes\">Aloe vera<\/jats:italic>\n                    gel extract against damage induced by whole-body X-ray exposure in male balb\/c mice. The animals were divided into four groups: Control,\n                    <jats:italic toggle=\"yes\">Aloe vera<\/jats:italic>\n                    (50\u00a0mg\/kg body weight orally on alternate days for 30 days), X-ray (cumulative dose of 2\u00a0Gy) (i.e., 0.258\u00a0Gy twice a day for four consecutive days) in the last week of the experimental protocol, and\n                    <jats:italic toggle=\"yes\">Aloe vera<\/jats:italic>\n                    + X-ray. Following irradiation, Fourier transform infrared spectroscopy (FTIR) analysis showed structural changes in molecules by altering the ratios of CH\n                    <jats:sub>3<\/jats:sub>\n                    \/lipid, CH\n                    <jats:sub>2<\/jats:sub>\n                    \/lipid, lipid\/protein, Amide I\/II, and nucleic acid in liver and testes. X-ray exposure led to an increase in DNA strand breaks in the liver, spleen, kidney, and testes of mice, as indicated by comet assay. Bcl-2 levels were shown to be up-regulated in the kidney and testes following irradiation. In liver, kidney, and spleen, caspase 3 was also found to be up-regulated. Furthermore, after being exposed to X-rays, the expression of caspase 9 and bax was up-regulated in all the tissues examined. Administration of\n                    <jats:italic toggle=\"yes\">Aloe vera<\/jats:italic>\n                    to the X-ray-exposed group exhibited decline in DNA strand breaks in all tissues investigated. Moreover, protein expressions of these genes were found to be down-regulated in the\n                    <jats:italic toggle=\"yes\">Aloe vera<\/jats:italic>\n                    + X-ray-exposed group. These observations illustrate the potential of\n                    <jats:italic toggle=\"yes\">Aloe vera<\/jats:italic>\n                    in providing radioprotection for rodents, possibly DNA protection, through its anti-apoptotic properties.\n                  <\/jats:p>","DOI":"10.1177\/07482337251400982","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:59:51Z","timestamp":1764647991000},"page":"11-28","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prophylactic effects of\n                    <i>Aloe vera<\/i>\n                    against X-ray irradiation\u2013induced structural alterations and DNA damage in mice"],"prefix":"10.1177","volume":"42","author":[{"given":"Shashi","family":"Bala","sequence":"first","affiliation":[{"name":"Panjab University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"PGIMER"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1938-3665","authenticated-orcid":false,"given":"Ashwani","family":"Koul","sequence":"additional","affiliation":[{"name":"Panjab University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.9734\/ajocs\/2020\/v7i419026"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2021.183726"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3280"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.110"},{"key":"e_1_3_5_6_1","first-page":"568","article-title":"Safety evaluation of Aloe vera pulp aqueous extract based on histoarchitectural and biochemical alterations in mice","volume":"55","author":"Bala S","year":"2017","unstructured":"Bala S, Chugh NA, Bansal SC, et al. 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