{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:35:24Z","timestamp":1777923324439,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100015034","name":"Shahid Sadoughi University of Medical Sciences","doi-asserted-by":"publisher","award":["9376"],"award-info":[{"award-number":["9376"]}],"id":[{"id":"10.13039\/501100015034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Lead is one of the main environment pollutants, which has strong inhibitory effects on the functioning of the CNS. Exposure to high amounts of lead, even shortly, stimulates glial cells and activates inflammatory pathways in brain. Lead can also increase the amount of oxidative stress. In this study, the effect of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) donors on lead-induced neurotoxicity was investigated. The protective effects of H\n                    <jats:sub>2<\/jats:sub>\n                    S have been proven in various neurological diseases. Lead and H\n                    <jats:sub>2<\/jats:sub>\n                    S were administered for 2\u00a0weeks. The animals\u2019 cognitive performance, exploratory behavior, and anxiety were evaluated using the shuttle box, open field, and elevated plus maze tests. The level of malondialdehyde (MDA), tumour necrosis factor alpha (TNF\u03b1), and interleukin 10 (IL-10); the total antioxidant capacity of the hippocampus; and blood lead levels were measured. Lead increased the level of TNF\u03b1 and MDA and decreased the level of IL-10 in the hippocampus. H\n                    <jats:sub>2<\/jats:sub>\n                    S was able to moderate the inflammatory and oxidative factors and tissue damage caused by lead in the hippocampus, which led to better cognitive and behavioral functions. The results of this study indicated that H\n                    <jats:sub>2<\/jats:sub>\n                    S reduced the damage caused by lead through its well-known antioxidant and anti-inflammatory activity, which ultimately resulted in improved behavioral and cognitive functions in lead-poisoned animals. .\n                  <\/jats:p>","DOI":"10.1177\/07482337261422818","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T14:06:48Z","timestamp":1770300408000},"page":"114-123","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of hydrogen sulfide donors on inflammatory and oxidative factors in the hippocampus of lead-poisoned rats"],"prefix":"10.1177","volume":"42","author":[{"family":"Keivan lorian","sequence":"first","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"},{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Azizian","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"},{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Yadegari","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasrin","family":"Alborzi","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"},{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynab","family":"Hafizi","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"},{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5702-2038","authenticated-orcid":false,"given":"Fatemeh Zare","family":"Mehrjerdi","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"},{"name":"Shahid Sadoughi University of Medical Sciences and Health Services"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.2399\/ana.17.015"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13530-020-00039-5"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13530-020-00073-3"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/intox-2015-0009"},{"issue":"3","key":"e_1_3_7_6_1","first-page":"45","article-title":"Down regulation of transforming growth factor-beta and interleukin-6 serum levels in the idiopathic chronic obstructive pulmonary disease","volume":"11","author":"Bahramabad R","year":"2022","unstructured":"Bahramabad R, Yousefi-Daredor H, Rezaeinejad S, et al. (2022) Down regulation of transforming growth factor-beta and interleukin-6 serum levels in the idiopathic chronic obstructive pulmonary disease. American Journal of Clinical and Experimental Immunology 11(3): 45\u201350.","journal-title":"American Journal of Clinical and Experimental Immunology"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0221-3"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2021.126919"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.014728"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.209783"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-20051-1"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00210"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-62170-4"},{"issue":"23","key":"e_1_3_7_14_1","first-page":"345","article-title":"Evaluation of lead acetate side effects on rat hippocampus and the effects of vitamin C on these","volume":"6","author":"Kermanian F","year":"2008","unstructured":"Kermanian F, Mahdizadeh M, Mahmoudian AR, et al. (2008) Evaluation of lead acetate side effects on rat hippocampus and the effects of vitamin C on these. Anatomical Sciences Journal 6(23): 345\u2013351. https:\/\/doi.org\/10.1016\/j.brainres.2007.09.044","journal-title":"Anatomical Sciences Journal"},{"key":"e_1_3_7_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22237"},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8249"},{"key":"e_1_3_7_17_1","first-page":"8090","article-title":"Effect of environmental exposure to hydrogen sulfide on central nervous system and respiratory function: a systematic review of human studies","volume":"22","author":"Lim E","year":"2016","unstructured":"Lim E, Mbowe O, Lee AS, et al. (2016) Effect of environmental exposure to hydrogen sulfide on central nervous system and respiratory function: a systematic review of human studies. International journal of occupational medicine and environmental health 22: 8090.","journal-title":"International journal of occupational medicine and environmental health"},{"key":"e_1_3_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-018-0577-z"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205012666150713102326"},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.12.009"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110841"},{"key":"e_1_3_7_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12091737"},{"key":"e_1_3_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010196"},{"key":"e_1_3_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2020-063950"},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02405-9"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1750-8870"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lmot.2021.101708"},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13530-023-00180-x"},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172530"},{"key":"e_1_3_7_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.265543"},{"key":"e_1_3_7_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathophysiology29030044"},{"key":"e_1_3_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413657"},{"key":"e_1_3_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7700"},{"key":"e_1_3_7_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16162895"},{"key":"e_1_3_7_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020323"},{"key":"e_1_3_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn500185g"},{"key":"e_1_3_7_37_1","first-page":"7301615","article-title":"Biologic effect of hydrogen sulfide and its role in traumatic brain injury","volume":"2020","author":"Zhang J","year":"2020","unstructured":"Zhang J, Zhang S, Shan H, et al. (2020) Biologic effect of hydrogen sulfide and its role in traumatic brain injury. Oxidative Medicine and Cellular Longevity 2020: 7301615 2020: 7301615. https:\/\/doi.org\/10.1155\/2020\/7301615","journal-title":"Oxidative Medicine and Cellular Longevity 2020: 7301615"},{"key":"e_1_3_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03840-5"},{"key":"e_1_3_7_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00702"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07482337261422818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07482337261422818","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07482337261422818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:44:51Z","timestamp":1777668291000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/07482337261422818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/07482337261422818"],"URL":"https:\/\/doi.org\/10.1177\/07482337261422818","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]}}}