{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:15:25Z","timestamp":1783210525232,"version":"3.54.6"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Center of Excellence on Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation"},{"name":"Thailand Science Research and Innovation (TSRI), Chulabhorn Research Institute","award":["2536704\/42293"],"award-info":[{"award-number":["2536704\/42293"]}]},{"name":"Thailand Science Research and Innovation (TSRI), Chulabhorn Research Institute","award":["53498\/4821838"],"award-info":[{"award-number":["53498\/4821838"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>Perfluorooctane sulfonate (PFOS) is a man-made chemical widely used in many products and acts as an endocrine-disrupting chemical (EDC). PFOS has spread to the environment through industrial manufacturing processes and disposal of PFOS-containing products. There is growing evidence that environmental pollutants may have promoting effects on cancer cell aggressiveness, rapid growth, and metastasis. Thyroid cancer is an endocrine-related cancer that can respond to EDCs. This study aimed to explore the effect of PFOS on the growth and metastatic potential (invasion capability) of FTC-133 human thyroid cancer cells. PFOS exposure for 72\u00a0h (1 pM to 10\u00a0\u00b5M) did not stimulate growth of FTC-133 cells. However, PFOS exposure at low concentration (1\u00a0nM) enhanced invasion capability of the cells, with no correlation to the expression level of estrogen receptors. FTC-133 cells exposed to 1\u00a0nM PFOS displayed increasing phosphorylation of multiple invasion-related signaling proteins, including Akt, ERK, and EphA2. Our study revealed that PFOS at low concentration may influence thyroid cancer progression by increasing the metastatic potential of cancer cells.<\/jats:p>","DOI":"10.1177\/07482337261461640","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:40:23Z","timestamp":1781628023000},"page":"320-327","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Perfluorooctane sulfonate (PFOS) increases metastatic potential of thyroid cancer cells in correlation with activation of multiple invasion-related signaling proteins"],"prefix":"10.1177","volume":"42","author":[{"given":"Phichamon","family":"Phetchahwang","sequence":"first","affiliation":[{"name":"Chulabhorn Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Monique","family":"Paricharttanakul","sequence":"additional","affiliation":[{"name":"Chulabhorn Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-5433","authenticated-orcid":false,"given":"Kriengsak","family":"Lirdprapamongkol","sequence":"additional","affiliation":[{"name":"Chulabhorn Research Institute"},{"name":"MHESI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisnuson","family":"Svasti","sequence":"additional","affiliation":[{"name":"Chulabhorn Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0728"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq379"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30172-6"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082411"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0EM00355G"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117529"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2474"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.11.018"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3475-2"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1736"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.1358"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-624"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0172"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-013-1753-3"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1836"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197304"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c03468"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jes.2023.09.031"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2021.1991775"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12249"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2661"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8149"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901584"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15194689"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00550.x"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv034"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10009"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.041"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-2077-8"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3210"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/es0303440"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104831"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2011.05.002"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.015339"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2015.12.008"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b17-00446"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07482337261461640","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07482337261461640","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07482337261461640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:22:21Z","timestamp":1783207341000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/07482337261461640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/07482337261461640"],"URL":"https:\/\/doi.org\/10.1177\/07482337261461640","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}