{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:35:32Z","timestamp":1777923332879,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1986,7,1]],"date-time":"1986-07-01T00:00:00Z","timestamp":520560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:p>\n                    The purpose of this study was to describe for asthmatic subjects the distribution of individual bronchial sensitivity to sulfur dioxide (SO2). Subjects were nonsmoking male asthmatics (n = 27) who were sensitive to inhaled methacholine. None of the subjects used corticosteroids or cromolyn sodium. Oral medications were with held for 48 hr, inhaled medications for 12 hr prior to all testing. Each subject participated in four separate randomly ordered 10 min exposures to 0.00, 0.25, 0.50 and 1.00 ppm SO\n                    <jats:sub>2<\/jats:sub>\n                    at 26\u00b0 C, 70% relative humidity. During exposures, subjects breathed naturally and performed moderate exercise (V\n                    <jats:sub>E<\/jats:sub>\n                    , normalized for body surface area = 21 l\/m\n                    <jats:sup>2<\/jats:sup>\n                    x min). Before and 3 min after exposure, specific airway resistance (SRaw) was measured by body plethysmography. Those subjects whose SRaw was not doubled by exposure to 1.00 ppm were also exposed to 2.00 ppm S02. Dose response curves (relative change in SRaw, corrected for change in clean air vs S02 concentration) were constructed for each subject. Bronchial sensi tivity to SO\n                    <jats:sub>2<\/jats:sub>\n                    [PC(SO2)], defined as the concentration of S02 which provoked an increase in SRaw 100% greater than the response to clean air, was determined. Substantial variability in sensitivity was observed: for 23 subjects, PC(SO2) ranged between 0.28 and 1.90 ppm, while for the remaining 4 subjects, it was greater than 2.00- ppm S02. The median PC(SO2) was 0.75 ppm SO\n                    <jats:sub>2<\/jats:sub>\n                    , and 6 subjects had a PC(SO\n                    <jats:sub>2<\/jats:sub>\n                    ) of less than 0.50 ppm. PC(SO\n                    <jats:sub>2<\/jats:sub>\n                    ) was not related (r = 0.31) to airway sensitivity to methacholine.\n                  <\/jats:p>","DOI":"10.1177\/074823378600200307","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T18:29:28Z","timestamp":1378751368000},"page":"289-298","source":"Crossref","is-referenced-by-count":44,"title":["Airway Sensitivity of Asthmatics To Sulfur Dioxide"],"prefix":"10.1177","volume":"2","author":[{"given":"Donald","family":"Horstman","sequence":"first","affiliation":[{"name":"Clinical Research Branch, Inhalation Toxicology Division Health Effects Research Laboratory United States Environmental Protection Agency Research Triangle Park, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jack","family":"Roger","sequence":"additional","affiliation":[{"name":"Environmental Monitoring Services, Inc. Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Kehrl","sequence":"additional","affiliation":[{"name":"Center for Environmental Medicine School of Medicine University of North Carolina Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Hazucha","sequence":"additional","affiliation":[{"name":"Center for Environmental Medicine School of Medicine University of North Carolina Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,7,1]]},"reference":[{"key":"atypb1","first-page":"987","volume":"128","author":"Bethel, R.A.","year":"1983","journal-title":"Am. Rev. Respir. Dis"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/jappl.1984.57.2.419","volume":"57","author":"Bethel, R.A.","year":"1984","journal-title":"J. Appl. Physiol.: Respirat. Environ. Exercise Physiol"},{"key":"atypb3","first-page":"389","volume":"121","author":"Boushey, H.A.","year":"1980","journal-title":"Am. Rev. Respir. Dis"},{"key":"atypb4","first-page":"1","author":"Cropp, G.J.A.","year":"1980","journal-title":"ATS News"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103282"},{"key":"atypb6","first-page":"739","volume":"114","author":"Haynes, R.L.","year":"1976","journal-title":"Amer. Rev. Resp. Dis"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1152\/jappl.1983.54.3.730","volume":"54","author":"Hazucha, M.J.","year":"1983","journal-title":"J. Appl. Physiol.: Respirat. Environ. Exercise Physiol"},{"key":"atypb8","first-page":"587","volume":"113","author":"Knudson, R.J.","year":"1976","journal-title":"Am. Rev. Respir. Dis"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1126\/science.218.4577.1113"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(83)90219-0"},{"key":"atypb11","first-page":"278","volume":"127","author":"Linn, W.S.","year":"1983","journal-title":"Am. Rev. Respir. Dis"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1152\/jappl.1983.54.5.1345","volume":"54","author":"Mcdonnell, W.F.","year":"1983","journal-title":"J. Appl. Physiol.: Respirat. Environ. Exercise Physiol"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.3.784"},{"key":"atypb14","first-page":"52","volume":"130","author":"Sheppard, D.","year":"1984","journal-title":"Am. Rev. Respirat. Dis"},{"key":"atypb15","volume-title":"Air Quality Criteria for Particulate Matter and Sulfur Dioxide","author":"United States Environmental Protection Agency.","year":"1985"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/074823378600200307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/074823378600200307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:45:45Z","timestamp":1777668345000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/074823378600200307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1177\/074823378600200307"],"URL":"https:\/\/doi.org\/10.1177\/074823378600200307","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}