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Freon 113 (0.2 mM) alone elicited significant atrioventricular conduction delay (p &gt; 0.05) and heart rate decrease (p &gt; 0.01), which were significantly enhanced by hypoxia (75% oxygen decrease), for instance, resulting in 2:1 AV block. The data suggest that arrhythmogenicity of Freon 113 on the heart conduction system may be enhanced synergistically by hypoxia.<\/jats:p>","DOI":"10.1177\/074823379000600310","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T18:34:01Z","timestamp":1378751641000},"page":"493-498","source":"Crossref","is-referenced-by-count":2,"title":["Enhanced Arrhythmogenicity of Freon 113 by Hypoxia in the Perfused Rat Heart"],"prefix":"10.1177","volume":"6","author":[{"given":"Tsuyoshi","family":"Kawakami","sequence":"first","affiliation":[{"name":"Department of Public Health and Environmental Science, Tokyo Medical and Dental University Faculty of Medicine, 1-5-45, Yushima, Bunkyo, Tokyo 113, JAPAN."},{"name":"Present address: National Institute of Industrial Health, 6-21-1, Nagao, Tama, Kanagawa 214, JAPAN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehito","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Public Health and Environmental Science, Tokyo Medical and Dental University Faculty of Medicine, 1-5-45, Yushima, Bunkyo, Tokyo 113, JAPAN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichiro","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Saitama Medical School, Moroyama-cho, Iruma-gun, Saitama 350-04, JAPAN."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,5,1]]},"reference":[{"key":"bibr1-074823379000600310","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.53.4.448"},{"key":"bibr2-074823379000600310","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2005"},{"key":"bibr3-074823379000600310","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(74)90040-7"},{"key":"bibr4-074823379000600310","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(75)90033-5"},{"key":"bibr5-074823379000600310","doi-asserted-by":"publisher","DOI":"10.1520\/JFS11071J"},{"key":"bibr6-074823379000600310","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.8.3.649"},{"key":"bibr7-074823379000600310","first-page":"32","volume":"26","author":"JAPANESE MINISTRY OF LABOR.","year":"1985","journal-title":"Occupational Health."},{"key":"bibr8-074823379000600310","first-page":"28","volume":"26","author":"JAPANESE MINISTRY OF LABOR.","year":"1985","journal-title":"Occupational Health."},{"key":"bibr9-074823379000600310","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.26.25"},{"key":"bibr10-074823379000600310","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2011"},{"key":"bibr11-074823379000600310","first-page":"52","volume":"174","author":"LESSARD Y.","year":"1980","journal-title":"C. 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