{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:38:39Z","timestamp":1777923519743,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:p>Piperonyl butoxide was administered to pregnant rats by gavage at a level of 0 (control), 630, 1065, and 1800 mg\/kg bw on days 11-12 of gestation. The animals were killed on day 20 of gestation. Average maternal body weight gain (gestational days 11-20) was significantly reduced in the 1065 and 1800 mg\/kg bw groups. Total resorption rate was significantly increased in the 1800 mg\/kg bw group and those effects were significantly dose-related. The average fetal body weight of each sex was significantly reduced in the 1065 and 1800 mg\/kg bw groups. External limb deformity (oligodactyly, syndactyly, and polydactyly) was significantly increased in the 1065 and 1800 mg\/kg bw groups in a dose- related manner. The dose levels of piperonyl butoxide in the present study produced limb deformities in rats.<\/jats:p>","DOI":"10.1177\/074823379501100205","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T18:38:14Z","timestamp":1378751894000},"page":"175-184","source":"Crossref","is-referenced-by-count":15,"title":["Developmental Toxicity Study of Piperonyl Butoxide in CD Rats"],"prefix":"10.1177","volume":"11","author":[{"given":"Toyohito","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Fujitani","sequence":"additional","affiliation":[{"name":"Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinshi","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,3,1]]},"reference":[{"key":"atypb1","first-page":"285","volume":"72","author":"Beltrame, D.","year":"1979","journal-title":"Rev. Biol."},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/62.3.569"},{"key":"atypb3","first-page":"1410","volume":"28","author":"Fritz, H.","year":"1978","journal-title":"Arzneim. Forsch."},{"key":"atypb4","unstructured":"Fujii, T. and Nakatsuka, T. (1984). \"Ontogeny of rats.\" In: Experimental Animal Science: Rats (M. Ishibashi, J. Takahashi, S. Sugawara , and Y. Yasuda, eds.). Koudansha Press, Tokyo. pp. 66-80 (in Japanese)."},{"key":"atypb5","first-page":"171","volume":"16","author":"Inouye, M.","year":"1976","journal-title":"Anom."},{"key":"atypb6","unstructured":"Ishibashi, M. (1984). \"Methods of staining of fetal skeleton in rats .\" In: Experimental Animal Science: Rats (M. Ishibashi, J. Takahashi , S. Sugawara, and Y. Yasuda, eds.). Koudansha Press, Tokyo. pp. 335-338 (in Japanese)."},{"key":"atypb7","first-page":"344","volume":"24","author":"Isshiki, K.","year":"1983","journal-title":"Soc. Japan"},{"key":"atypb8","first-page":"25","volume":"20","author":"Kameyama, Y.","year":"1980","journal-title":"Cong. Anom."},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-6264(77)80207-1"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(79)90330-2"},{"key":"atypb11","doi-asserted-by":"crossref","unstructured":"Kochhar, D.M. (1979). \"Abnormal organogenesis in the limbs.\" In: Handbook of Teratology. 2. Mechanisms and Pathogenesis (J.G. Wilson and F.C. Fraser, eds.). 2nd ed. Plenum Press, New York. pp. 453-479.","DOI":"10.1007\/978-1-4615-8933-4_18"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(85)90156-5"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1987.tb00703.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-3219-0_5"},{"key":"atypb15","first-page":"293","volume":"26","author":"Perraud, J.","year":"1976","journal-title":"Sci."},{"key":"atypb16","first-page":"424","volume":"18","author":"Shimomura, K.","year":"1993","journal-title":"J. Toxicol. Sci."},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1033"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050098"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(92)90050-T"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(92)90112-X"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(94)90172-4"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/074823379501100205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/074823379501100205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:50:05Z","timestamp":1777668605000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/074823379501100205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1177\/074823379501100205"],"URL":"https:\/\/doi.org\/10.1177\/074823379501100205","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}