{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:37:33Z","timestamp":1777923453679,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>\n                    We studied 14 unmedicated sulfur dioxide (S02)-sensitive asthmatics to test the hypothesis that SO\n                    <jats:sub>2<\/jats:sub>\n                    exacerbates asthma more than other everyday respiratory stressors. In Phase I, subjects underwent controlled exposures to 0.0, 0.5, and 1.0 ppm SO\n                    <jats:sub>2<\/jats:sub>\n                    with light, medium, and heavy exercise (average ventilation 30, 36, and 43 l\/min, respectively). Lung function, symptoms of asthma, and psychophysical (stamina) changes were measured. Function, symptom, and stamina responses correlated modestly. Increasing SO\n                    <jats:sub>2<\/jats:sub>\n                    had stronger unfavorable effects than increasing exercise. In Phase II, subjects performed eight different physical tasks in SO\n                    <jats:sub>2<\/jats:sub>\n                    -free ambient air while symptoms and stamina were measured. Fast stair-climbing evoked symptoms similar to the effects of 0.5 ppm SO\n                    <jats:sub>2<\/jats:sub>\n                    \/light exercise, while stamina reduction was comparable to 0.5 ppm SO\n                    <jats:sub>2<\/jats:sub>\n                    \/heavy exercise. In Phase III, subjects recorded time-activity patterns, symptoms, and stamina during randomly selected intervals on a typical weekday and weekend day. Most reported activities were sedentary. Infrequent, strenuous Phase III exercise increased symptoms more than did 0.5 ppm SO\n                    <jats:sub>2<\/jats:sub>\n                    \/light exercise, but with less effect on stamina. We conclude that for typical mild asthmatics, ten-minute SO\n                    <jats:sub>2<\/jats:sub>\n                    exposures at concentrations &gt;0.5 ppm andventilation &gt;30 l\/min can cause short-term asthma manifestations more intense than those usually experienced from everyday stresses without SO\n                    <jats:sub>2<\/jats:sub>\n                    exposure.\n                  <\/jats:p>","DOI":"10.1177\/074823379501100502","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T18:39:04Z","timestamp":1378751944000},"page":"467-487","source":"Crossref","is-referenced-by-count":30,"title":["Comparative Short-Term Health Responses To Sulfur Dioxide Exposure and Other Common Stresses in a Panel of Asthmatics"],"prefix":"10.1177","volume":"11","author":[{"suffix":"JR","given":"Henry","family":"Gong","sequence":"first","affiliation":[{"name":"Rancho Los Amigos Medical Center Downey, California and University of Southern California School of Medicine Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Lachenbruch","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Harber","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Linn","sequence":"additional","affiliation":[{"name":"Rancho Los Amigos Medical Center Downey, California and University of Southern California School of Medicine Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,9,1]]},"reference":[{"key":"atypb1","unstructured":"Afifi, A.A. and Azen, S.P. 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