{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:39:32Z","timestamp":1777923572993,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>Subchronic exposure to the PCB congener 77 (PCB 77) and 28 (PCB 28) was previously shown to induce histological changes in the thyroid and in the brain biogenic amines levels, suggesting possible effects on thyroid and reproductive hormone levels. Thus, the effects of a 90-day dietary exposure to PCB 28 or 77 on luteinizing hormone, follicle-stimulating hormone, and testosterone concentrations were studied in male rats, as well as the levels of thyroid-stimulating hormone, thyroxine (T4) and uridine diphosphate-glucuronyl transferase (UDP-GT) activity in both genders. Weanling Sprague Dawley rats were randomly distributed into groups of 10 rats and were fed, for the next 13 weeks, purina lab chow containing 50, 500, 5000, or 50 000 ppb of PCB 28 or 10, 100, 1000, or 10 000 ppb of PCB 77. The serum concentrations of T4 were decreased in rats of both sexes receiving 1000 ppb or more of PCB 77, and was associated with an increased activity of UDP-GT which reached significance only in the females. There was a tendency for the highest dose of PCB 28 also to decrease serum T4 concentrations in the female rats. None of the PCB treatments significantly altered gonadotropin, TSH, or testosterone concentrations. These results suggest that thyroid functions may be more susceptible or adapt less readily than the pituitary gland and the testes to endocrine disruption caused by PCB congeners.<\/jats:p>","DOI":"10.1177\/074823379701300504","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T18:40:54Z","timestamp":1378752054000},"page":"627-638","source":"Crossref","is-referenced-by-count":26,"title":["Reproductive and Thyroid Hormone Levels in Rats Following 90-Day Dietary Exposure To Pcb 28 (2,4,4'-Trichlorobiphenyl) or Pcb 77 (3,3',4,4'-Tetrachlorobiphenyl)"],"prefix":"10.1177","volume":"13","author":[{"given":"Daniel","family":"Desaulniers","sequence":"first","affiliation":[{"name":"Reproductive Toxicology Section Environmental and Occupational Toxicology Division Bureau of Chemical Hazards, Environmental Health Directorate Health Protection Branch, Health Canada Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Poon","sequence":"additional","affiliation":[{"name":"Reproductive Toxicology Section Environmental and Occupational Toxicology Division Bureau of Chemical Hazards, Environmental Health Directorate Health Protection Branch, Health Canada Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Phan","sequence":"additional","affiliation":[{"name":"Reproductive Toxicology Section Environmental and Occupational Toxicology Division Bureau of Chemical Hazards, Environmental Health Directorate Health Protection Branch, Health Canada Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Leingartner","sequence":"additional","affiliation":[{"name":"Reproductive Toxicology Section Environmental and Occupational Toxicology Division Bureau of Chemical Hazards, Environmental Health Directorate Health Protection Branch, Health Canada Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren G.","family":"Foster","sequence":"additional","affiliation":[{"name":"Reproductive Toxicology Section Environmental and Occupational Toxicology Division Bureau of Chemical Hazards, Environmental Health Directorate Health Protection Branch, Health Canada Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IH","family":"Chu","sequence":"additional","affiliation":[{"name":"Reproductive Toxicology Section Environmental and Occupational Toxicology Division Bureau of Chemical Hazards, Environmental Health Directorate Health Protection Branch, Health Canada Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"atypb1","unstructured":"Bardin C.W., Cheng, C.Y., Mustow, N.A., and Gunsalus, G.L. (1994). \"The Sertoli cell.\" In: The Physiology of Reproduction. (E. Knobil and J.D. Neill, eds.) 2nd Ed. Raven Press, Ltd., New York, NY. 1994:1291-1333."},{"key":"atypb2","first-page":"189","volume":"45","author":"Barraclough, C.A.","year":"1994","journal-title":"Acta. Biol. Hung."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(92)90006-E"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-2-741"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197204"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(90)90255-R"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90337-6"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(81)77022-8"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF01066399"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1007\/BF01055530"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1007\/BF01056331"},{"key":"atypb13","volume":"4257","author":"Cadogan, J.I.G.","year":"1962","journal-title":"J. Chem. Soc."},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1995.1099"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1080\/00984108.1996.11667603"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0013"},{"key":"atypb17","doi-asserted-by":"crossref","unstructured":"Cutler-Linder, C. and Griswold, M.D. (1993). \"Stage synchronization in rat seminiferous tubules using vitamin A depletion and repletion.\" In: Methods in Toxicology. Volume 3, Part A: Male Reproductive Toxicology. ( R.E. Chapin and J.J. Heindel, eds.) Academic Press, Inc., Toronto, Canada. pp. 95-105.","DOI":"10.1016\/B978-0-12-461207-5.50010-9"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1987.tb01772.x"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.3109\/00498258609043532"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(95)00220-3"},{"key":"atypb21","first-page":"117","volume":"12","author":"Desaulniers, D.","year":"1995","journal-title":"Endocrinol."},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.11.8895349"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(93)90225-V"},{"key":"atypb24","first-page":"1","volume":"7","author":"Foster, W.G.","year":"1992","journal-title":"Toxicol."},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-5-2521"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(93)90230-5"},{"key":"atypb27","unstructured":"JMP (1989). Software for Statistical Visualization on the Apple Mcintosh. Version 2. SAS Institute Inc. Cary, NC. USA."},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1988.9934366"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1210\/endo-108-6-2346"},{"key":"atypb30","first-page":"559","volume":"131","author":"Kirby, J.D.","year":"1992","journal-title":"Endocrinology"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(93)90081-9"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.0166"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(91)90287-N"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1020095"},{"key":"atypb35","first-page":"225","volume":"14","author":"Maier, W.E.","year":"1994","journal-title":"Toxicol."},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.3.8603575"},{"key":"atypb37","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0272-0590(89)90326-6","volume":"13","author":"Marks, T.A.","year":"1989","journal-title":"Fundam. Appl. Toxicol."},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1210\/endo-121-4-1233"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1021\/jm00384a014"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(89)90083-0"},{"key":"atypb41","author":"Moir, D.","year":"1996","journal-title":"Toxicol. Ind. Health"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1210\/endo-121-1-432"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1080\/15287399409531934"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(93)90023-Q"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(90)90203-6"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1480043"},{"key":"atypb47","unstructured":"Parkinson, A. (1996). \"Biotransformation of xenobiotics.\" In: Casarett and Doull's Toxicology: The Basic Science of Poisons. 5th Ed. (C.D. Klaassen, M.O. Amdur, and J. Doull , eds.) McGraw-Hill, New York, NY. pp. 113-186."},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1991.tb01250.x"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1021\/jf00061a007"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(90)90113-9"},{"key":"atypb51","volume-title":"Thirteenth international neurotoxicology conference","author":"Seegal, R.F."},{"key":"atypb52","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90131-W"},{"key":"atypb53","unstructured":"Sharpe, R.M. \"Regulation of spermatogenesis.\" In: The Physiology of Reproduction. 2nd Ed. ( E. Knobil and J.D. Neill, eds.) Raven Press, Ltd., New York, NY. pp. 1363-1434."},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.3109\/00498259309059366"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.1159\/000181836"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/074823379701300504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/074823379701300504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:50:55Z","timestamp":1777668655000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/074823379701300504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1177\/074823379701300504"],"URL":"https:\/\/doi.org\/10.1177\/074823379701300504","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}