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Dopamine and melatonin contents in the eye are robustly rhythmic under constant conditions; dopamine levels are high during the subjective day, and melatonin levels are high during the subjective night. Dopamine and melatonin affect the amplitude of the b-wave in an antagonistic and phase-dependent manner: dopamine D2-receptor agonists injected intraocularly during the subjective night produce high-amplitude b-waves characteristic of the subjective day, whereas melatonin injected intraocularly during the subjective day reduces b-wave amplitude. Sectioning the optic nerve abolishes the circadian rhythms of b-wave amplitude and of dopamine content. The results of this study suggest that in iguana, a negative feedback loop involving dopamine and melatonin regulates the circadian rhythm of the ERG b-wave amplitude that is at least in part generated in the brain.<\/jats:p>","DOI":"10.1177\/0748730402238235","type":"journal-article","created":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T18:54:26Z","timestamp":1239994466000},"page":"526-538","source":"Crossref","is-referenced-by-count":29,"title":["Circadian Rhythm of Iguana Electroretinogram: The Role of Dopamine and Melatonin"],"prefix":"10.1177","volume":"17","author":[{"given":"Manuel","family":"Miranda-Anaya","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda, Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, DF 04510; Department of Biology and National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, VA 22904, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Bartell","sequence":"additional","affiliation":[{"name":"Forschungsstelle f\u00fcr Ornithologie der Max-Planck-Gesellschaft, D-82346 Erling-Andechs, Germany; Department of Biology and National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, VA 22904, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Menaker","sequence":"additional","affiliation":[{"name":"Department of Biology and National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, VA 22904, USA; Department of Biology, Gilmer Hall, University of Virginia, P.O. 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