{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:54:26Z","timestamp":1790639666842,"version":"4.1.0"},"reference-count":77,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T00:00:00Z","timestamp":1522800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"German Wildlife Foundation"},{"name":"DREAL Alsace"},{"DOI":"10.13039\/501100013413","name":"R\u00e9gion Alsace","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013413","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Strasbourg Institute of Advanced Studies"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG Mo 1742\/1-1"],"award-info":[{"award-number":["DFG Mo 1742\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biol Rhythms"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Adaptation of biological rhythms to a seasonal environment in circannual mammals is achieved via the synchronization of intrinsic circannual rhythms to the external year by photoperiod. In mammals, the photoperiodic information is integrated to seasonal physiology via the pineal hormone melatonin regulation of pars tuberalis (PT) TSH\u03b2 expression and its downstream control of hypothalamic dio2 gene expression. In the circannual European hamster, however, photoperiodic entrainment of the circannual clock is possible in pinealectomized animals. The present study explores whether the TSH\u03b2 expression in the PT and the downstream hypothalamic pathways are regulated by photoperiod in European hamsters in the absence of melatonin. All animals were kept on an accelerated photoperiodic regime, which compressed the natural year to a 6-month cycle. Sham-operated European hamsters and half of the pinealectomized European hamsters entrained their annual cycle in reproduction, body weight, and activity pattern to this cycle, whereas the other half of the pinealectomized animals followed only each second cycle. In all animals, PT TSH\u03b2 and hypothalamic dio2 expressions were higher in hamsters displaying a summer physiological state than in those in winter state. Moreover, in agreement with their seasonal state, reproductive animals (summer state) showed higher expression of rfrp and lower expression of kiss1\u2014genes encoding central regulators of the reproductive axis\u2014than those animals in reproductive quiescence (winter state), indicating the hypothalamic integration of the photoperiodic signal even in pinealectomized animals. The appropriate occurrence of a well-characterized activity pattern indicative of a so-called sensitive phase to short photoperiod suggested that the SCN constructs the melatonin-independent photoperiodic message. This message is sufficient to entrain the circannual rhythm in TSH\u03b2 expression in the PT and the downstream hypothalamic neuroendocrine pathway through a yet unknown pathway. These results reinforce the hypothesis that the PT is the site for the integration of circannual and photoperiodic information.<\/jats:p>","DOI":"10.1177\/0748730418766601","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:41:57Z","timestamp":1522888917000},"page":"302-317","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Melatonin-independent Photoperiodic Entrainment of the Circannual TSH Rhythm in the Pars Tuberalis of the European Hamster"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-035X","authenticated-orcid":false,"given":"Cristina","family":"S\u00e1enz de Miera","sequence":"first","affiliation":[{"name":"Department of Neurobiology of Rhythms, Institute for Cellular and Integrative Neuroscience, University of Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Sage-Ciocca","sequence":"additional","affiliation":[{"name":"Chronobiotron UMS3415-CNRS, University of Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Simonneaux","sequence":"additional","affiliation":[{"name":"Department of Neurobiology of Rhythms, Institute for Cellular and Integrative Neuroscience, University of Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"P\u00e9vet","sequence":"additional","affiliation":[{"name":"Department of Neurobiology of Rhythms, Institute for Cellular and Integrative Neuroscience, University of Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Monecke","sequence":"additional","affiliation":[{"name":"Department of Neurobiology of Rhythms, Institute for Cellular and Integrative Neuroscience, University of Strasbourg, Strasbourg, France"},{"name":"Institute of Chronoecology, Stuttgart, Germany, and Ludwig Maximilians University, Institute of Medical Psychology, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,4,4]]},"reference":[{"key":"bibr1-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1622"},{"key":"bibr2-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1177\/0748730410361918"},{"key":"bibr3-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.6.8833"},{"key":"bibr4-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.00988.x"},{"key":"bibr5-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0316"},{"key":"bibr6-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.1995.tb00798.x"},{"key":"bibr7-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168954"},{"key":"bibr8-0748730418766601","first-page":"113","volume":"28","author":"Canguilhem B","year":"1974","journal-title":"Arch Sci Physiol"},{"key":"bibr9-0748730418766601","volume":"19","author":"Dardente H","year":"2014","journal-title":"Front Endocrinol 5:Art"},{"key":"bibr10-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01060.x"},{"key":"bibr11-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.10.048"},{"key":"bibr12-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1604"},{"key":"bibr13-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-82870-6"},{"key":"bibr14-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.06.076"},{"key":"bibr15-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1140221"},{"key":"bibr16-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1038\/nature01761"},{"key":"bibr17-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1177\/0748730411420812"},{"key":"bibr18-0748730418766601","volume":"36","author":"Henningsen JB","year":"2016","journal-title":"Front Endocrinol 7:Art"},{"key":"bibr19-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091530103"},{"key":"bibr20-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00208-0"},{"key":"bibr21-0748730418766601","first-page":"67","volume-title":"Chronobiology: Biological Timekeeping","author":"Johnson CH","year":"2004"},{"key":"bibr22-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04148.x"},{"key":"bibr23-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod41.6.1034"},{"key":"bibr24-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1177\/41.3.8429209"},{"key":"bibr25-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-229559"},{"key":"bibr26-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.1994.tb00580.x"},{"key":"bibr27-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132009"},{"key":"bibr28-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212517599"},{"key":"bibr29-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2667-x"},{"key":"bibr30-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305781"},{"key":"bibr31-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1987.tb00843.x"},{"key":"bibr32-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.11.038"},{"key":"bibr33-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9938"},{"key":"bibr34-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.03.020"},{"key":"bibr35-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1177\/0748730406290315"},{"key":"bibr36-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1177\/0748730409344502"},{"key":"bibr37-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1177\/0748730413498561"},{"key":"bibr38-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.023002"},{"key":"bibr39-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-005-0472-6"},{"key":"bibr40-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-55261-1_14"},{"key":"bibr41-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(96)00083-6"},{"key":"bibr42-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.4.R987"},{"key":"bibr43-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006393107"},{"key":"bibr44-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07586.x"},{"key":"bibr45-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1007\/s003590100215"},{"key":"bibr46-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00173.x"},{"key":"bibr47-0748730418766601","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s004410051226","volume":"295","author":"Ozawa H","year":"1999","journal-title":"Cell Tissue Res"},{"key":"bibr48-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-550150-7.50011-4"},{"key":"bibr49-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2003.03132.x"},{"key":"bibr50-0748730418766601","first-page":"275","volume-title":"Updates on Integrative Physiology and Comparative Endocrinology","author":"P\u00e9vet P","year":"2016"},{"key":"bibr51-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1007\/BF01417859"},{"key":"bibr52-0748730418766601","first-page":"1","volume":"3","author":"Rasri-Klosen K","year":"2017","journal-title":"J Neuroendocrinol"},{"key":"bibr53-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.07.025"},{"key":"bibr54-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0848"},{"key":"bibr55-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1999.tb00561.x"},{"key":"bibr56-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00503.x"},{"key":"bibr57-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12013"},{"key":"bibr58-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.05.024"},{"key":"bibr59-0748730418766601","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00022"},{"key":"bibr60-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.4.8462468"},{"key":"bibr61-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0581"},{"key":"bibr62-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0712"},{"key":"bibr63-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901600102"},{"key":"bibr64-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24026"},{"key":"bibr65-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05421.x"},{"key":"bibr66-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2010.03.001"},{"key":"bibr67-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1110"},{"key":"bibr68-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.01.048"},{"key":"bibr69-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(92)90107-U"},{"key":"bibr70-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1006\/gcen.1996.6853"},{"key":"bibr71-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1126\/science.309.5734.551"},{"key":"bibr72-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.1989.tb00122.x"},{"key":"bibr73-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1007\/BF01133417"},{"key":"bibr74-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.09.014"},{"key":"bibr75-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2017.06.029"},{"key":"bibr76-0748730418766601","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2013.852104"},{"key":"bibr77-0748730418766601","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-0930-7"}],"container-title":["Journal of Biological Rhythms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748730418766601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0748730418766601","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748730418766601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:58:47Z","timestamp":1777492727000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748730418766601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,4]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1177\/0748730418766601"],"URL":"https:\/\/doi.org\/10.1177\/0748730418766601","relation":{},"ISSN":["0748-7304","1552-4531"],"issn-type":[{"value":"0748-7304","type":"print"},{"value":"1552-4531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,4]]}}}