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There is a vascular portal pathway between the SCN and the organum vasculosum of the lamina terminalis in mouse brain. Portal pathways enable low concentrations of neurosecretions to reach specialized local targets without dilution in the systemic circulation. To explore the SCN vasculature and the capillary vessels whereby SCN neurosecretions might reach portal vessels, we investigated the blood vessels (BVs) of the core and shell SCN. The arterial supply of the SCN differs among animals, and in some animals, there are differences between the 2 sides. The rostral SCN is supplied by branches from either the superior hypophyseal artery (SHpA) or the anterior cerebral artery or the anterior communicating artery. The caudal SCN is consistently supplied by the SHpA. The rostral SCN is drained by the preoptic vein, while the caudal is drained by the basal vein, with variations in laterality of draining vessels. In addition, several key features of the core and shell SCN regions differ: Median BV diameter is significantly smaller in the shell than the core based on confocal image measurements, and a similar trend occurs in iDISCO-cleared tissue. In the cleared tissue, whole BV length density and surface area density are significantly greater in the shell than the core. Finally, capillary length density is also greater in the shell than the core. The results suggest three hypotheses: First, the distinct arterial and venous systems of the rostral and caudal SCN may contribute to the in vivo variations of metabolic and neural activities observed in SCN networks. Second, the dense capillaries of the SCN shell are well positioned to transport blood-borne signals. Finally, variations in SCN vascular supply and drainage may contribute to inter-animal differences.<\/jats:p>","DOI":"10.1177\/07487304231189537","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T01:26:30Z","timestamp":1691544390000},"page":"571-585","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Vasculature of the Suprachiasmatic Nucleus: Pathways for Diffusible Output Signals"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-8802","authenticated-orcid":false,"given":"Yifan","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Psychology, Columbia University, New York City, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella K.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Psychology, Columbia University, New York City, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana B.","family":"Taub","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Barnard College, New York City, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruya","family":"Tazebay","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Barnard College, New York City, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"LeSauter","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Barnard College, New York City, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rae","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Psychology, Columbia University, New York City, NY"},{"name":"Department of Neuroscience and Behavior, Barnard College, New York City, NY"},{"name":"Department of Pathology and Cell Biology, Columbia University, New York City, NY"},{"name":"Zuckerman Institute, Columbia University, New York City, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02890-6"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00331261"},{"key":"e_1_3_3_4_1","first-page":"21","article-title":"Blood supply of the rat hypothalamus. 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