{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:55:00Z","timestamp":1777791300267,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100021054","name":"Military Operational Medicine Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biol Rhythms"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>The purpose of this study was twofold: (a) to determine whether, and the extent to which, the challenge of a single night of total sleep deprivation (TSD) unmasks lingering brain health-related deficits in individuals who within the past 3 to 12\u2009months had been diagnosed (yet medically cleared) with a mild traumatic brain injury (mTBI+), and (b) to determine whether mTBI+ results in any neurophysiobehavioral deficits in the ability to recover from TSD. Seven previously concussed (mTBI+) adults (24.5 \u00b1 5.3 years old) and six non-concussed control (mTBI\u2212) adults underwent 24\u2009h TSD preceded by 8\u2009h baseline sleep (BSL) and followed by 8\u2009h recovery sleep (REC). Study measures included the psychomotor vigilance test (PVT) across the entire study and polysomnography during nighttime sleep and daytime nap tests. mTBI+ (vs mTBI\u2212) subjects exhibited more minor lapses on the PVT across all study phases. NREM (N3) sleep and total sleep time (TST) amounts were lower and wake after sleep onset (WASO) was higher in mTBI+ subjects (vs mTBI) at baseline and REC. mTBI+ (vs mTBI\u2212) subjects showed no main effects in maintenance of wakefulness across TSD. Although there is some evidence that TSD may unmask latent performance deficits in mTBI+ subjects, a definitive conclusion was precluded by differences in baseline sleep in mTBI+ (vs mTBI\u2212) subjects, suggesting that they may habitually carry a relatively elevated sleep debt (vs mTBI\u2212 controls). Reversal of TSD-induced neurophysiobehavioral deficits following recovery sleep were comparable for both groups, revealing no significant abnormalities in the responsivity of the sleep homeostat in the mTBI+ subjects.<\/jats:p>","DOI":"10.1177\/07487304251385057","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:02:07Z","timestamp":1765976527000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Can a Single Night of Sleep Deprivation Unmask Human Sleep and Neurophysiobehavioral Impairments During the Post-Acute Phase of Mild Traumatic Brain Injury?"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-8461","authenticated-orcid":false,"given":"Allison","family":"Brager","sequence":"first","affiliation":[{"name":"Center for Military Psychiatry and Neuroscience, Behavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"},{"name":"Department of Behavioral Sciences and Leadership, United States Military Academy, West Point, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Edwards","sequence":"additional","affiliation":[{"name":"National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassie","family":"Pattinson","sequence":"additional","affiliation":[{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"St. Pierre-Paul","sequence":"additional","affiliation":[{"name":"Center for Military Psychiatry and Neuroscience, Behavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antigone","family":"Grillakis","sequence":"additional","affiliation":[{"name":"Center for Military Psychiatry and Neuroscience, Behavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janna","family":"Mantua","sequence":"additional","affiliation":[{"name":"Center for Military Psychiatry and Neuroscience, Behavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Peyer","sequence":"additional","affiliation":[{"name":"National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Balkin","sequence":"additional","affiliation":[{"name":"Center for Military Psychiatry and Neuroscience, Behavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent F.","family":"Capaldi","sequence":"additional","affiliation":[{"name":"Center for Military Psychiatry and Neuroscience, Behavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Gill","sequence":"additional","affiliation":[{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"},{"name":"Department of Neurology, School of Nursing, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Yarnell","sequence":"additional","affiliation":[{"name":"Center for Military Psychiatry and Neuroscience, Behavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2004.00407.x"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2003.00337.x"},{"key":"e_1_3_3_4_1","first-page":"195","article-title":"A two-process model of sleep regulation","volume":"1","author":"Borb\u00e9ly AA","year":"1982","unstructured":"Borb\u00e9ly AA (1982) A two-process model of sleep regulation. Human Neurobiol 1:195-204.","journal-title":"Human Neurobiol"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112154"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5423.2177"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3138"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2017.09.020"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868811"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2018.01.004"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx062"},{"key":"e_1_3_3_12_1","article-title":"Intra-individual increase of homeostatic sleep pressure across acute and chronic sleep loss: a high-density EEG study","volume":"40","author":"Maric A","year":"2017","unstructured":"Maric A, Lustenberger C, Werth E, Baumann CR, Poryazova R, Huber R (2017) Intra-individual increase of homeostatic sleep pressure across acute and chronic sleep loss: a high-density EEG study. Sleep 40:Zsx122.","journal-title":"Sleep"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.6.1300"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3246"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3274-15.2016"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq388"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.10.024"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7148-0_3"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2010"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12483"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.12.023"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.11356"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.20.2.224"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.08.003"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5117"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12068"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3284"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.03.017"},{"key":"e_1_3_3_29_1","first-page":"73","article-title":"Enhancing sleep slow waves with natural stimuli","volume":"54","author":"Tononi G","year":"2010","unstructured":"Tononi G, Riedner BA, Hulse BK, Ferrarelli F, Sarasso S (2010) Enhancing sleep slow waves with natural stimuli. Medicamundi 54:73-79.","journal-title":"Medicamundi"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2007.00594.x"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(95)00029-3"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa224"}],"container-title":["Journal of Biological Rhythms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07487304251385057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07487304251385057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07487304251385057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:03:07Z","timestamp":1777492987000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/07487304251385057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/07487304251385057"],"URL":"https:\/\/doi.org\/10.1177\/07487304251385057","relation":{},"ISSN":["0748-7304","1552-4531"],"issn-type":[{"value":"0748-7304","type":"print"},{"value":"1552-4531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]}}}