{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:07:55Z","timestamp":1789153675836,"version":"build-2803163510"},"reference-count":90,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["Advanced Grant CLOCKrisk (grant number 101053225)"],"award-info":[{"award-number":["Advanced Grant CLOCKrisk (grant number 101053225)"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biol Rhythms"],"abstract":"<jats:p>Chronic kidney disease (CKD) affects roughly 10% of the world\u2019s population, and growing evidence suggests that disruption of the circadian system\u2014now recognized as an important regulator of numerous physiological pathways, may contribute to impaired kidney function and increased CKD risk. This narrative review aims to synthesize the existing literature on the association between determinants of circadian rhythm (shift work, artificial light at night [ALAN], melatonin) as well as sleep health and CKD risk. Three databases (PubMed, Web of Science, and Embase) were searched for original articles published from 1966 through 28 February 2026. A total of 34 studies examined the association between circadian factors and CKD risk: 7 on shift work, 2 on ALAN, 4 on melatonin, 4 on chronotype, 2 on social jetlag, 2 on insomnia, and 18 on sleep duration. Taken together, these studies offer consistent evidence that shift work, evening chronotype, prolonged social jetlag, and both short and long sleep duration are associated with elevated CKD risk. Given the potential implications for early detection, risk stratification, and targeted behavioral interventions, future research should employ standardized approaches and improved measures using, for example, actigraphy, to clarify causal pathways and strengthen the evidence base.<\/jats:p>","DOI":"10.1177\/07487304261477969","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:46:21Z","timestamp":1789015581000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Circadian System and Chronic Kidney Disease Risk: Epidemiological Evidence"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8828-499X","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7641-9245","authenticated-orcid":false,"given":"Dat","family":"Thien Tran","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tala","family":"El Ghoul","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0589-4173","authenticated-orcid":false,"given":"Magdalena","family":"\u017bebrowska","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-2056","authenticated-orcid":false,"given":"Susanne","family":"Strohmaier","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6845-7505","authenticated-orcid":false,"given":"Dilara","family":"G\u00fclmez","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8047-2395","authenticated-orcid":false,"given":"Manfred","family":"Hecking","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4337-9415","authenticated-orcid":false,"given":"Eva S.","family":"Schernhammer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria"},{"name":"Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy070"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2019.03.001"},{"key":"e_1_3_2_4_1","article-title":"Association of insomnia and short sleep duration, alone or with comorbid obstructive sleep apnea, and the risk of chronic kidney disease","volume":"45","author":"Beaudin AE","year":"2022","unstructured":"Beaudin AE, Raneri JK, Ahmed S, Hirsch Allen AJ, Nocon A, Gomes T, Gakwaya S, Series F, Kimoff JR, Skomro R, et al. (2022) Association of insomnia and short sleep duration, alone or with comorbid obstructive sleep apnea, and the risk of chronic kidney disease. Sleep 45:zsac088.","journal-title":"Sleep"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44323-025-00024-6"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7660"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124543"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr007"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.5.585"},{"key":"e_1_3_2_10_1","first-page":"2017","article-title":"Association between weekend catch-up sleep and chronic kidney disease: insights from NHANES","volume":"47","author":"Chen S","year":"2025","unstructured":"Chen S, Zhang T, Gao H, Zhang J (2025) Association between weekend catch-up sleep and chronic kidney disease: insights from NHANES 2017-2020. Ren Fail 47:2461682.","journal-title":"Ren Fail"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-33130-1"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.400"},{"key":"e_1_3_2_13_1","first-page":"91","article-title":"Meal timing and frequency implications in the development and prognosis of chronic kidney disease","author":"Costa NA","year":"2021","unstructured":"Costa NA, Pereira AG, Dorna MS, Rodrigues HCN, Azevedo PS, Paiva SAR, Polegato BF, Balbi AL, Zornoff LAM, Ponce D, et al. (2021) Meal timing and frequency implications in the development and prognosis of chronic kidney disease. Nutrition 91-92:111427.","journal-title":"Nutrition"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.3c00021"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI148286"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31694-5"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00820-6"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02825-4"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01853-7"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-025-04518-x"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.08.028"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2098"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.03.010"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.24.285"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-022-01854-8"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02488-w"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-023-03177-3"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40101-024-00380-5"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158765"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612820666140929092929"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-024-02575-7"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19996"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-015-1224-x"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-214713"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531261"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531440"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.018"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2026.119055"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24266"},{"key":"e_1_3_2_40_1","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2024","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group (2024) KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int 105:S117-S314.","journal-title":"Kidney Int"},{"key":"e_1_3_2_41_1","article-title":"Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women","volume":"12","author":"Kim CW","year":"2017","unstructured":"Kim CW, Chang Y, Sung E, Yun KE, Jung HS, Ko BJ, Kwon MJ, Hyun YY, Lee KB, Kim H, et al. (2017) Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women. PLOS ONE 12:e0175298.","journal-title":"PLOS ONE"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2569986"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520801921572"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.35371\/aoem.2023.35.e22"},{"key":"e_1_3_2_45_1","article-title":"The association of sleep duration with the risk of chronic kidney disease: a systematic review and meta-analysis","volume":"17","author":"Koh JH","year":"2024","unstructured":"Koh JH, Yeo BSY, Tan TWE, See MYS, Ng ACW, Loh SRH, Gooley J, Tan CS, Toh ST (2024) The association of sleep duration with the risk of chronic kidney disease: a systematic review and meta-analysis. Clin Kidney J 17:sfae177.","journal-title":"Clin Kidney J"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19283"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.70031"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12995-023-00393-3"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2023.111323"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106752"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16234238"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000638"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2710"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060838"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.741171"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-016-0506-6"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20150202"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI148277"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11040487"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504545"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081600"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1929-18"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.06.020"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2025.40.e224"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-023-03861-1"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1159\/000548489"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00557.2012"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2021.12.010"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.03.038"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26929"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40795-025-01026-0"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-017-1508-3"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000000322"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.20.1563"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01225-4"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2073"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112270"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00405"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.08.007"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2022.100458"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.04.027"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40557-018-0279-z"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.4454"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031562"},{"key":"e_1_3_2_85_1","first-page":"85","article-title":"Overview of circadian rhythms","volume":"25","author":"Vitaterna MH","year":"2001","unstructured":"Vitaterna MH, Takahashi JS, Turek FW (2001) Overview of circadian rhythms. Alcohol Res Health 25:85-93.","journal-title":"Alcohol Res Health"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.12.007"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500545979"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214776"},{"key":"e_1_3_2_89_1","article-title":"Sleep patterns, genetic susceptibility, and incident chronic kidney disease: a prospective study of 370 671 participants","volume":"16","author":"Zhang H","year":"2022","unstructured":"Zhang H, Wang B, Chen C, Sun Y, Chen J, Tan X, Xia F, Zhang J, Lu Y, Wang N (2022) Sleep patterns, genetic susceptibility, and incident chronic kidney disease: a prospective study of 370 671 participants. Front Neurosci 16:725478.","journal-title":"Front Neurosci"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12964"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17239035"}],"container-title":["Journal of Biological Rhythms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07487304261477969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07487304261477969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07487304261477969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:16:35Z","timestamp":1789150595000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/07487304261477969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":90,"alternative-id":["10.1177\/07487304261477969"],"URL":"https:\/\/doi.org\/10.1177\/07487304261477969","relation":{},"ISSN":["0748-7304","1552-4531"],"issn-type":[{"value":"0748-7304","type":"print"},{"value":"1552-4531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"article-number":"07487304261477969"}}