{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:33:49Z","timestamp":1777790029302,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biol Rhythms"],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>The gene that suppresses the phenotype of the cpz-2mutation, which results in changing the sensitivity to chlorpromazine in relation to mycelial growth and circadian rhythms, was cloned in Neurospora crassa.This gene is not the cpz-2 gene itself but rather is identical to the spe-3gene that encodes spermidine synthase in Neurospora. The intracellular content of spermidine was lowered in the cpz-2strain compared to that of the wild-type strain. By integration of the spe-3 gene or by the addition of spermidine into culture medium, the temperature sensitivity of mycelial growth was lost and the conidiation rhythm became sensitive to chlorpromazine in the cpz-2 strain, as was observed in the wild-type strain, but the hypersensitivity of mycelial growth on chlorpromazine in the cpz-2strain was not affected. Therefore, it appears that spermidine determines only the sensitivity of the conidiation rhythm to chlorpromazine.<\/jats:p>","DOI":"10.1177\/074873098129000282","type":"journal-article","created":{"date-parts":[[2004,5,27]],"date-time":"2004-05-27T09:25:01Z","timestamp":1085649901000},"page":"452-460","source":"Crossref","is-referenced-by-count":8,"title":["Spermidine Determines the Sensitivity to the Calmodulin Antagonist, Chlorpromazine, for the Circadian Conidiation Rhythm but Not for the Mycelial Growth in\n                    <i>Neurospora crassa<\/i>"],"prefix":"10.1177","volume":"13","author":[{"given":"Satoshi","family":"Katagiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Onai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, 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