{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:32:22Z","timestamp":1777811542169,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>\n                    Staurosporine was previously shown to mobilize Ca\n                    <jats:sup>2+<\/jats:sup>\n                    from the thapsigargin-insensitive Ca\n                    <jats:sup>2+<\/jats:sup>\n                    store in rat submandibular acinar cells. However, the nature of the store is not yet known. Therefore, in the present study, the staurosporine-releasable intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    store was characterized. Staurosporine increased the cytosolic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    concentration ([Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>c<\/jats:sub>\n                    ) after the inositol 1,4,5-trisphosphate (IP\n                    <jats:sub>3<\/jats:sub>\n                    )-sensitive Ca\n                    <jats:sup>2+<\/jats:sup>\n                    store was depleted. Ionomycin caused only small increases in [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>c<\/jats:sub>\n                    after the depletion of the IP\n                    <jats:sub>3<\/jats:sub>\n                    -sensitive Ca\n                    <jats:sup>2+<\/jats:sup>\n                    store, whereas ionomycin+monensin caused large increases. However, ionomycin+monensin did not increase [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>c<\/jats:sub>\n                    when added after [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>c<\/jats:sub>\n                    was increased by staurosporine, indicating that the acidic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    store was the main source of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    . The acidic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    store appeared to be associated with secretory granules, since ionomycin+monensin- and staurosporine-induced [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>c<\/jats:sub>\n                    increases were significantly reduced when the acinar cells were degranulated. The effect of staurosporine on [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>c<\/jats:sub>\n                    was mimicked by other protein kinase C inhibitors. Therefore, we conclude that staurosporine mobilizes Ca\n                    <jats:sup>2+<\/jats:sup>\n                    from secretory granules, probably through the inhibition of protein kinase C in rat submandibular acinar cells.\n                  <\/jats:p>","DOI":"10.1177\/0810788","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T17:05:01Z","timestamp":1483635901000},"page":"788-793","source":"Crossref","is-referenced-by-count":2,"title":["Staurosporine Mobilizes Ca\n                    <sup>2+<\/sup>\n                    from Secretory Granules by                Inhibiting Protein Kinase C in Rat Submandibular Acinar Cells"],"prefix":"10.1177","volume":"81","author":[{"given":"Y.J.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Oral Biology & Oral Science Research Center, BK21 Project for Medical Sciences, Yonsei University College of Dentistry, Shinchon-dong 134, Seodaemoon-gu, Seoul 120-752, Korea; and"},{"name":"Department of Physiology and Research Institute of Oral Science,\r               Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"An","sequence":"additional","affiliation":[{"name":"Department of Oral Biology & Oral Science Research Center, BK21 Project for Medical Sciences, Yonsei University College of Dentistry, Shinchon-dong 134, Seodaemoon-gu, Seoul 120-752, Korea; and"},{"name":"Department of Physiology and Research Institute of Oral Science,\r               Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.M.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Oral Biology & Oral Science Research Center, BK21 Project for Medical Sciences, Yonsei University College of Dentistry, Shinchon-dong 134, Seodaemoon-gu, Seoul 120-752, Korea; and"},{"name":"Department of Physiology and Research Institute of Oral Science,\r               Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-I.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral Biology & Oral Science Research Center, BK21 Project for Medical Sciences, Yonsei University College of Dentistry, Shinchon-dong 134, Seodaemoon-gu, Seoul 120-752, Korea; and"},{"name":"Department of Physiology and Research Institute of Oral Science,\r               Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sugiya","sequence":"additional","affiliation":[{"name":"Department of Oral Biology & Oral Science Research Center, BK21 Project for Medical Sciences, Yonsei University College of Dentistry, Shinchon-dong 134, Seodaemoon-gu, Seoul 120-752, Korea; and"},{"name":"Department of Physiology and Research Institute of Oral Science,\r               Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.T.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Oral Biology & Oral Science Research Center, BK21 Project for Medical Sciences, Yonsei University College of Dentistry, Shinchon-dong 134, Seodaemoon-gu, Seoul 120-752, Korea; and"},{"name":"Department of Physiology and Research Institute of Oral Science,\r               Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"BERRIDGE-1993","doi-asserted-by":"publisher","DOI":"10.1038\/361315a0"},{"key":"CASE-ETAL-1986","unstructured":"Case RM, Ansah TA, Dho S, Howorth AJ, Argent BE\n                  -1986- Second messenger interactions in pancreas and salivary\n               glands. 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