{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:31:58Z","timestamp":1783467118587,"version":"3.55.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>Concurrent with the decline in dental caries has been an increase in the prevalence of dental fluorosis, a side-effect of exposure to greater than optimal levels of fluoride during amelogenesis. The mechanisms that underlie the pathogenesis of dental fluorosis are not known. We hypothesize that genetic determinants influence an individual\u2019s susceptibility or resistance to develop dental fluorosis. We tested this hypothesis using a mouse model system (continuous eruption of the incisors) where genotype, age, gender, food, housing, and drinking water fluoride level can be rigorously controlled. Examination of 12 inbred strains of mice showed differences in dental fluorosis susceptibility\/resistance. The A\/J mouse strain is highly susceptible, with a rapid onset and severe development of dental fluorosis compared with that in the other strains tested, whereas the 129P3\/J mouse strain is least affected, with minimal dental fluorosis. These observations support the contribution of a genetic component in the pathogenesis of dental fluorosis.<\/jats:p>","DOI":"10.1177\/0810794","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T17:05:01Z","timestamp":1483635901000},"page":"794-798","source":"Crossref","is-referenced-by-count":87,"title":["Dental Fluorosis: Variability among Different Inbred Mouse                Strains"],"prefix":"10.1177","volume":"81","author":[{"given":"E.T.","family":"Everett","sequence":"first","affiliation":[{"name":"Oral-Facial Genetics Division,"},{"name":"Department of Oral Facial Development,"},{"name":"Graduate Program in Pediatric Dentistry,"},{"name":"Department of Preventive and Community Dentistry, and"},{"name":"Oral Health Research Institute, Indiana University School of\r               Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.K.","family":"McHenry","sequence":"additional","affiliation":[{"name":"Oral-Facial Genetics Division,"},{"name":"Department of Oral Facial Development,"},{"name":"Graduate Program in Pediatric Dentistry,"},{"name":"Department of Preventive and Community Dentistry, and"},{"name":"Oral Health Research Institute, Indiana University School of\r               Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Oral-Facial Genetics Division,"},{"name":"Department of Oral Facial Development,"},{"name":"Graduate Program in Pediatric Dentistry,"},{"name":"Department of Preventive and Community Dentistry, and"},{"name":"Oral Health Research Institute, Indiana University School of\r               Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Eggertsson","sequence":"additional","affiliation":[{"name":"Oral-Facial Genetics Division,"},{"name":"Department of Oral Facial Development,"},{"name":"Graduate Program in Pediatric Dentistry,"},{"name":"Department of Preventive and Community Dentistry, and"},{"name":"Oral Health Research Institute, Indiana University School of\r               Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Oral-Facial Genetics Division,"},{"name":"Department of Oral Facial Development,"},{"name":"Graduate Program in Pediatric Dentistry,"},{"name":"Department of Preventive and Community Dentistry, and"},{"name":"Oral Health Research Institute, Indiana University School of\r               Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kantmann","sequence":"additional","affiliation":[{"name":"Oral-Facial Genetics Division,"},{"name":"Department of Oral Facial Development,"},{"name":"Graduate Program in Pediatric Dentistry,"},{"name":"Department of Preventive and Community Dentistry, and"},{"name":"Oral Health Research Institute, Indiana University School of\r               Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.","family":"Martinez-Mier","sequence":"additional","affiliation":[{"name":"Oral-Facial Genetics Division,"},{"name":"Department of Oral Facial Development,"},{"name":"Graduate Program in Pediatric Dentistry,"},{"name":"Department of Preventive and Community Dentistry, and"},{"name":"Oral Health Research Institute, Indiana University School of\r               Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Warrick","sequence":"additional","affiliation":[{"name":"Oral-Facial Genetics Division,"},{"name":"Department of Oral Facial Development,"},{"name":"Graduate Program in Pediatric Dentistry,"},{"name":"Department of Preventive and Community Dentistry, and"},{"name":"Oral Health Research Institute, Indiana University School of\r               Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.K.","family":"Stookey","sequence":"additional","affiliation":[{"name":"Oral-Facial Genetics Division,"},{"name":"Department of Oral Facial Development,"},{"name":"Graduate Program in Pediatric Dentistry,"},{"name":"Department of Preventive and Community Dentistry, and"},{"name":"Oral Health Research Institute, Indiana University School of\r               Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"ANGMAR-MANSSON-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1177\/08959374940080011301"},{"key":"ANGMAR-MANSSON-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1996.tb00116.x"},{"key":"AOBA-AND-FEJERSKOV-2002","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300206"},{"key":"ATCHLEY-AND-FITCH-1991","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948030"},{"key":"BECK-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1038\/71641"},{"key":"CLARK-1994","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1994.tb01832.x"},{"key":"FERREIRA-ZANDONA-ETAL-2000","unstructured":"Ferreira-Zandona AG, Analoui M, Beiswanger BB,\n               Isaacs RL, Kafrawy AH, Eckert GJ,\n                      et al\n                      .2000- Indiana pilot\n               clinical study of quantitative light fluorescence. In: Early detection of dental\n               caries: proceedings of the 4th Annual Indiana Conference. Stookey GK, editor.\n               Indianapolis: Indiana University, pp. 219-230."},{"key":"KATSURA-ETAL-1994","doi-asserted-by":"crossref","unstructured":"Katsura I, Kondo K, Amano T, Ishihara T, Kawakami M\n                  -1994- Isolation, characterization and epistasis of\n               fluoride-resistant mutants of\n                      Caenorhabditis elegans\n                      .\n                  Genetics 136:145\u2013154.","DOI":"10.1093\/genetics\/136.1.145"},{"key":"MASCARENHAS-2000","unstructured":"Mascarenhas AK -2000- Risk factors for\n               dental fluorosis: a review of the recent literature. Pediatr Dent 22:269\u2013277."},{"key":"MOINICHEN-ETAL-1996","unstructured":"Moinichen CB, Lyngstadaas SP, Risnes S\n                  -1996- Morphological characteristics of mouse incisor enamel.\n                  J Anat 189:325\u2013333."},{"key":"NESS-1965","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(65)90109-3"},{"key":"PENDRYS-2000","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2000.0273"},{"key":"RICHARDS-1990","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690S136"},{"key":"ROJAS-SANCHEZ-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Rojas-Sanchez F, Kelly SA, Drake KM, Eckert GJ,\n               Stookey GK, Dunipace AJ -1999- Fluoride intake from foods, beverages\n               and dentifrice by young children in communities with negligibly and optimally\n               fluoridated water: a pilot study. 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