{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:19:19Z","timestamp":1777922359003,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Fonds Brigitte Perreault - Fondation du CHUS"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Palliat Care"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Respiratory distress protocols (RDPs) are protocolized prescriptions comprised of 3 medications (a benzodiazepine, an opioid, and an anticholinergic) administered simultaneously as an emergency treatment for respiratory distress in palliative care patients in the province of Quebec, Canada. However, data on appropriate use that justifies the combination of all 3 components is scarce and based on individual pharmacodynamic properties along with expert consensus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Our study aimed to evaluate the conformity and the effectiveness of RDPs prescribed and administered to hospitalized adult patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a prospective and descriptive study conducted in a single center. Prescription and administration conformity were assessed based on predefined appropriateness criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 467 adult patients were prescribed a RDP, 175 administrations were documented, and 78 patients received at least 1 RDP. Prescription conformity was assessed on 1473 separate occasions over the trial period. Overall prescription conformity was found to be 37% (95% confidence interval [CI]: 33.6-40.4), and administration conformity was 37.7% (95% CI: 26.2-50.7). Low administration conformity was primarily explained by incorrect indications for RDP use. Seemingly important determinants of higher conformity were prescriber\u2019s speciality in palliative care, use of preprinted orders, pharmacist involvement, and hospitalization in the palliative care unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights important gaps in the use of RDPs in our institution. Health-care provider training appears necessary in order to ensure adequate conformity and allow for further evaluation of RDP effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0825859719835555","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T04:44:23Z","timestamp":1553229863000},"page":"21-28","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Conformity in Prescription and Administration of Respiratory Distress Protocols in a Tertiary Care Hospital in the Province of Quebec: RELIEVE Study"],"prefix":"10.1177","volume":"35","author":[{"given":"Camille","family":"Dufort-Rouleau","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installations H\u00f4tel-Dieu et Fleurimont, Sherbrooke, Quebec, Canada"},{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installations H\u00f4tel-Dieu et Fleurimont, Sherbrooke, Quebec, Canada"},{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Centre int\u00e9gr\u00e9 de sant\u00e9 et de services sociaux de Lanaudi\u00e8re \u2013 Centre hospitalier Pierre-Le Gardeur, Terrebonne, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Barr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installations H\u00f4tel-Dieu et Fleurimont, Sherbrooke, Quebec, Canada"},{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installation H\u00f4pital de Granby, Granby, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"B\u00e9dard","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installations H\u00f4tel-Dieu et Fleurimont, Sherbrooke, Quebec, Canada"},{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installation H\u00f4pital d\u2019Asbestos, Asbestos, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9milie Dufort","family":"Rouleau","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installations H\u00f4tel-Dieu et Fleurimont, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-France","family":"Beauchesne","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installations H\u00f4tel-Dieu et Fleurimont, Sherbrooke, Quebec, Canada"},{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Quenneville","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installations H\u00f4tel-Dieu et Fleurimont, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Berteau","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie\u2014Centre hospitalier universitaire de Sherbrooke, Installations H\u00f4tel-Dieu et Fleurimont, Sherbrooke, Quebec, 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