{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:00:44Z","timestamp":1789524044909,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Palliat Care"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Malignant Pleural Mesothelioma (MPM) has a poor prognosis and high symptom burden. RESPECT-Meso was a multicenter randomized study examining the role of early specialist palliative care (SPC) on quality of life (QoL) with MPM. This is a post-hoc exploratory analysis of the symptom burden and unmet needs identified from RESPECT-Meso participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Exploratory analysis from 174 participants using the General Health Status (GHS) measure (from the EORTC QLQ-C30 QoL questionnaire) and 87 participants using validated assessment questionnaires in those randomized to SPC. Eligibility for the study included confirmed MPM with diagnosis &lt;6 weeks prior, performance score (PS) 0 or 1, no significant physical or psychological comorbidity. Cox proportional hazards models were derived to examine for relationships with survival. Free text was assessed using content analysis, looking for common themes and words.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Participants were predominantly male (79.9%), mean age 72.8 years, PS was 0 in 38%, 78% of MPM was epithelioid. At least 3 symptoms were reported in 69.8% of participants, including fatigue (81%), dyspnea (73.3%), pain (61.2%), weight loss (59.3%). Anxiety was reported by 54.7% of participants, 52.3% low mood and 48.8% anhedonia symptoms. After multivariable adjustment, only pain remained statistically significant with a hazard ratio (HR) 2.9 (95% CI 1.3-6.7; p = 0.01). For each 1 unit increase in GHS score, the HR for death was 0.987 (0.978-0.996; p = 0.006), indicating a worse reported QoL is related to shorter survival. Unmet needs were common: 25.9% wanted more information about their condition, 24.7% about their care and 21.2% about their treatment. 79.1% were concerned about the effect of their illness on family.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a high symptom burden in mesothelioma despite good baseline performance status. A worse QoL is associated with a worse survival. Unmet needs are common, perhaps highlighting a need for improved communication and information sharing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0825859720948975","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T10:31:23Z","timestamp":1597401083000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Symptom Burden and Unmet Needs in Malignant Pleural Mesothelioma: Exploratory Analyses From the RESPECT-Meso Study"],"prefix":"10.1177","volume":"36","author":[{"given":"Siao Nge","family":"Hoon","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"},{"name":"Curtin Medical School, Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8830-7220","authenticated-orcid":false,"given":"Iain","family":"Lawrie","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, North Manchester General Hospital, Manchester, United Kingdom"},{"name":"Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Qi","sequence":"additional","affiliation":[{"name":"Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najib","family":"Rahman","sequence":"additional","affiliation":[{"name":"Oxford Respiratory Trials Unit, University of Oxford, Oxford, United Kingdom"},{"name":"National Institute for Health Research Oxford Biomedical Research Centre, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Maskell","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Forbes","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Gerry","sequence":"additional","affiliation":[{"name":"Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-9619","authenticated-orcid":false,"given":"Leanne","family":"Monterosso","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery, University of Notre Dame, Fremantle, Australia"},{"name":"School of Nursing and Midwifery, Edith Cowan University"},{"name":"St John of God Murdoch Hospital, Murdoch, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom"},{"name":"Research & Innovation Department, Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom"},{"name":"School of Health Sciences and Social Work, University of Portsmouth, Portsmouth, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-7535","authenticated-orcid":false,"given":"Fraser J. 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