{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:19:54Z","timestamp":1777922394731,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Palliat Care"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In efforts to reduce misuse of opioids, new abuse deterrent formulations of medications have been developed. Insurers increasingly give abuse-deterrent opioid formulations preferred formulary status, which can result in required formulation rotation for patients. Xtampza\u00ae (oxycodone myristate extended-release) is an abuse-deterrent opioid formulation that maintains its extended-release properties with any physical manipulation. Blood levels of oxycodone myristate extended-release (OxyM-ER) may vary with dietary caloric and fat intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Description:<\/jats:title>\n                    <jats:p>A woman with metastatic breast carcinoma had severe myalgias and arthralgias well-managed with oxycodone hydrochloride extended-release (OxyHCl-ER) and hydrocodone\/acetaminophen. A switch from OxyHCl-ER to OxyM-ER resulted in worsened pain management, decreased functional status, and a referral to palliative care (PC). Recognizing calorie-depending pharmacokinetic variability with OxyM-ER, the interdisciplinary PC team obtained a detailed dietary history from the patient, which revealed a low-fat, low-calorie healthy diet with inconsistent meals. After repeated education, the patient changed her diet and had improved pain and functional status without increasing her total daily opioid dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The efficacy of OxyM-ER may be compromised in patients with cancer experiencing anorexia, decreased or inconsistent food intake, or low-fat\/low-calorie diets. An interdisciplinary team approach can improve pain control in the setting of \u201cforced\u201d formulary switches to OxyM-ER.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0825859720981330","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T12:37:41Z","timestamp":1608208661000},"page":"148-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Food on Bioavailability of Oxycodone Myristate: A Case Report"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-2634","authenticated-orcid":false,"given":"Theodore Pham","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice and Sciences, University of Iowa College of Pharmacy, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-2137","authenticated-orcid":false,"given":"Yuya","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-5244","authenticated-orcid":false,"given":"Carla","family":"Pies","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kashelle","family":"Lockman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Sciences, University of Iowa College of Pharmacy, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"issue":"4","key":"bibr1-0825859720981330","first-page":"175","volume":"2","author":"Nokhodchi A","year":"2012","journal-title":"BioImpacts"},{"key":"bibr2-0825859720981330","unstructured":"Guidance for Industry Abuse-Deterrent Opioids\u2014Evaluation and Labeling. US Department of Health and Human Services, Food and Drug Administration and Center for Drug Evaluation and Research. FDA Guid Ind. 2015; 1\u201326. https:\/\/www.fda.gov\/files\/drugs\/published\/Abuse-Deterrent-Opioids-Evaluation-and-Labeling.pdf"},{"key":"bibr3-0825859720981330","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12834"},{"key":"bibr4-0825859720981330","unstructured":"Xtampza [Full Prescribing Information]. Collegium Pharmaceutical, Inc; 2018."},{"key":"bibr5-0825859720981330","unstructured":"Nallani SC. Food Effect with Xtampza ER. Food and Drug Administration, Center for Drug Evaluation and Research. Joint Meeting of the Anesthetic and Analgesic Drug Products Advisory Committee and the Drug Safety and Risk Management Advisory Committee. 2015."},{"key":"bibr6-0825859720981330","unstructured":"FDA Advisory Committee Briefing Document: Xtampza ER. FDA Advisory Committee Meeting. 1\u201393. 2015."},{"key":"bibr7-0825859720981330","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00506-8"},{"key":"bibr8-0825859720981330","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20168"}],"container-title":["Journal of Palliative Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0825859720981330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0825859720981330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0825859720981330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:19:29Z","timestamp":1777666769000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0825859720981330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/0825859720981330"],"URL":"https:\/\/doi.org\/10.1177\/0825859720981330","relation":{},"ISSN":["0825-8597","2369-5293"],"issn-type":[{"value":"0825-8597","type":"print"},{"value":"2369-5293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,17]]}}}