{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:26Z","timestamp":1792787666856,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"JSPS KAKENHI","award":["23K10970"],"award-info":[{"award-number":["23K10970"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Palliat Care"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the associations of nutrition impact symptoms (NISs) with sleep disturbance among advanced cancer patients receiving palliative care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A secondary analysis of a self-administered survey was performed. Participants evaluated 3 components of sleep disturbance (ie, difficulty falling asleep, difficulty staying asleep, and early awakening) and 19 NISs using numerical rating scales (0-10). They also used several screening tools, including the Hospital Anxiety and Depression Scale (HADS). Finally, 2 groups were analyzed by multivariate logistic regression analysis using a cutoff score of 4 for each of the 3 components (&lt; 4, lower score group; \u2265 4, higher score group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ultimately, 184 patients were included. For all 3 components, higher score groups had significantly greater numbers of NISs with a score \u2265 4 and higher anxiety and depression than lower score groups. In the logistic regression model using HADS-Anxiety for difficulty falling asleep, significantly higher adjusted odds ratios (ORs) were observed in the 4-6 NISs (with a score \u2265 4) group than in the no NISs (with a score \u2265 4) group (7.15 [95% confidence interval (CI), 1.24-41.06]). Using HADS-Depression for difficulty falling asleep and difficulty staying asleep, significantly higher adjusted ORs were observed in the 4-6 NISs group than in the no NISs group (7.43 [95% CI, 1.29-42.74]; 4.47 [95% CI, 1.02-19.69, respectively]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Having 4 or more NISs with a score \u2265 4 was significantly associated with sleep disturbance. Cachexia-related symptom management is essential to improve patients\u2019 sleep status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08258597261433339","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T14:22:03Z","timestamp":1774102923000},"page":"413-423","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Nutrition Impact Symptoms With Sleep Disturbance Among Patients With Advanced Cancer Referred to Palliative Care: A Secondary Analysis of a Multicenter Survey"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-6389","authenticated-orcid":false,"given":"Koji","family":"Amano","sequence":"first","affiliation":[{"name":"Osaka International Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-8706","authenticated-orcid":false,"given":"Saori","family":"Koshimoto","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Institute of Science Tokyo"},{"name":"Faculty of Health Promotional Sciences, Department of Health and Nutritional Sciences, Tokoha University, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Okamura","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital East"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Matsuda","sequence":"additional","affiliation":[{"name":"NHO Kinki Chuo Chest Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Tokoro","sequence":"additional","affiliation":[{"name":"NHO Kinki Chuo Chest Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuma","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Kansai Medical University Kori Hospital"},{"name":"Aichi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoharu","family":"Mori","sequence":"additional","affiliation":[{"name":"Aichi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Arakawa","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Satomi","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamiki","family":"Wada","sequence":"additional","affiliation":[{"name":"Osaka University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Wada","sequence":"additional","affiliation":[{"name":"Osaka International Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Institute of Science Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.028"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13163990"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2025.114909"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13742"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adm8857"},{"issue":"3","key":"e_1_3_3_9_2","first-page":"167","article-title":"Psychological symptoms of illness and emotional distress in advanced cancer cachexia","volume":"25","author":"Amano K","year":"2022","unstructured":"Amano K, Hopkinson J, Baracos V. 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