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The increased utilization of screening examinations has led to growing demands for rapid and accurate diagnostic reporting. In modern breast imaging centers, full-field digital mammography (FFDM) has replaced traditional analog mammography, and this has opened new opportunities for developing computational frameworks to automate detection and diagnosis. Artificial intelligence (AI), and its subdomain of deep learning, is showing promising results and improvements on diagnostic accuracy, compared to previous computer-based methods, known as computer-aided detection and diagnosis.<\/jats:p>\n                  <jats:p>In this commentary, we review the current status of computational radiology, with a focus on deep neural networks used in breast cancer screening and diagnosis. Recent studies are developing a new generation of computer-aided detection and diagnosis systems, as well as leveraging AI-driven tools to efficiently interpret digital mammograms, and breast tomosynthesis imaging. The use of AI in computational radiology necessitates transparency and rigorous testing. However, the overall impact of AI to radiology workflows will potentially yield more efficient and standardized processes as well as improve the level of care to patients with high diagnostic accuracy.<\/jats:p>","DOI":"10.1177\/0846537120949974","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T07:32:40Z","timestamp":1598859160000},"page":"98-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":75,"title":["Computational Radiology in Breast Cancer Screening and Diagnosis Using Artificial Intelligence"],"prefix":"10.1177","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0733-7234","authenticated-orcid":false,"given":"William T.","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada"},{"name":"Department of Radiation Oncology, University of Toronto, Toronto, 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