{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:37:24Z","timestamp":1783125444439,"version":"3.54.6"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To explore the association between carotid artery length and tortuosity, and the occurrence of stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>In this retrospective study, IRB approved, 411 consecutive patients (males: 245; median age: 56 \u00b1 12 years, age range: 21-93 years) with anterior circulation ischemic stroke were included. Only patients that underwent CTA within 7 days were considered and stroke caused by cardiac embolism and thoracic aorta embolism were excluded. For each patient, both carotid arteries were considered, and the ICA, CCA-ICA length and tortuosity were calculated. Inter-observer analysis was quantified with the Bland-Altman test. Mann-Whitney test and logistic regression analysis were also calculated to test the association between length and tortuosity with the occurrence of stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the final analysis, 166 patients (males: 72; median age: 54 \u00b1 12 years, age range: 24-89 years) with anterior circulation ischemic stroke that were admitted to our hospital between February 2008 and December 2013 were included. The results showed a good concordance for the length of the vessels with a mean variation of 0.7% and 0.5% for CCA-ICA and ICA length respectively an for the tortuosity with a mean variation of 0.2% and -0.4% for CCA-ICA and ICA respectively. The analysis shows a statistically significant association between the tortuosity index of the ICA and CCA-ICA sides with stroke ( P value = 0.0001 in both cases) and these findings were confirmed also with the logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Results of this study suggest that tortuosity index is associated with the presence of stroke whereas the length of the carotid arteries does not play a significant role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0846537121991057","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T12:50:38Z","timestamp":1614775838000},"page":"789-796","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Does Carotid Artery Tortuosity Play a Role in Stroke?"],"prefix":"10.1177","volume":"72","author":[{"given":"Luca","family":"Saba","sequence":"first","affiliation":[{"name":"Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Monserrato (Cagliari), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Azienda Ospedaliero Universitaria (A.O.U.), Monserrato (Cagliari), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasjit S.","family":"Suri","sequence":"additional","affiliation":[{"name":"Stroke Monitoring and Diagnostic Division, AtheroPoint\u2122, Roseville, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0579-3279","authenticated-orcid":false,"given":"Filippo","family":"Cademartiri","sequence":"additional","affiliation":[{"name":"SDN, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Corrias","sequence":"additional","affiliation":[{"name":"Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Monserrato (Cagliari), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Mannelli","sequence":"additional","affiliation":[{"name":"SDN, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Zucca","sequence":"additional","affiliation":[{"name":"Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Monserrato (Cagliari), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Senis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Monserrato (Cagliari), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Montisci","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Azienda Ospedaliero Universitaria (A.O.U.), Monserrato (Cagliari), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Wintermark","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"bibr1-0846537121991057","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000074"},{"key":"bibr2-0846537121991057","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016643553"},{"key":"bibr3-0846537121991057","volume-title":"Neurological Therapeutics: Principles and Practice","author":"Phan 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