{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:35:53Z","timestamp":1785796553094,"version":"3.56.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Genetic Aortic Disorders Association Canada"},{"DOI":"10.13039\/501100024676","name":"Department of Medical Imaging, University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024676","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Loeys-Dietz Syndrome Foundation Canada"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    Vascular Ehlers-Danlos syndrome (vEDS) is a rare and aggressive heritable aortic disease caused by pathogenic variants in COL3A1 gene, characterized by spontaneous arterial dissection and organ rupture. The purpose of this study is to evaluate ventricular size and function and to explore their associations with complications in vEDS.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Adults with genetically confirmed vEDS who underwent clinical cardiac MRI were retrospectively compared with controls matched for age and sex. Cardiac MRI analysis included assessment of ventricular volumetry and arterial vasculature. vEDS-related complications were evaluated including dissection, aneurysm, and pneumothorax. Multivariable logistic regression was performed.\n                    <jats:bold>Results:<\/jats:bold>\n                    We studied 26 individuals with vEDS (38.6 \u00b1 15.6 years, 50.0% female) and 26 healthy controls. Median clinical follow-up was 2.4 (1.1-3.6) years. Left and right ventricular ejection fractions were lower in vEDS compared with controls (LVEF 58 \u00b1 6% vs 61 \u00b1 4%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .03; RVEF 54 \u00b1 5% vs 58 \u00b1 4%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .03). After controlling for age, sex, and antihypertensive medication, LV end-diastolic volume indexed to body surface area (LVEDVi) predicted dissections (OR 1.1, 95% CI 1.01-1.2,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .04) and aneurysms (OR 1.1, 95% CI 1.01-1.3,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .03). Indexed LV end systolic volume (LVESVi) also predicted aneurysms (OR 1.2, 95% CI 1.03-1.5,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .02). LVEF predicted the presence of any complication (OR 0.71, 95% CI 0.52-0.99,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .04). Pneumothorax occurred exclusively in vEDS group among those with LVEF &lt;58% (below the mean), 50.0% versus 0.0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .02. Those with LVEF &lt;58% had more frequent dissection and\/or aneurysm (75.0% vs 12.5%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .04).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Lower LVEF and larger cardiac size are associated with complications in vEDS.\n                  <\/jats:p>","DOI":"10.1177\/08465371241278523","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T01:06:40Z","timestamp":1725671200000},"page":"161-170","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Cardiac Size, Systolic Function, and Complications in Vascular Ehlers-Danlos Syndrome"],"prefix":"10.1177","volume":"76","author":[{"given":"Aly","family":"Fawzy","sequence":"first","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Warnica","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3077-2218","authenticated-orcid":false,"given":"Kate","family":"Hanneman","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, University of Toronto, Toronto, ON, Canada"},{"name":"Joint Department of Medical Imaging, University Medical Imaging Toronto, Toronto General Hospital, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Wald","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging, University Medical Imaging Toronto, Toronto General Hospital, Toronto, ON, Canada"},{"name":"Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-8494","authenticated-orcid":false,"given":"Erwin","family":"Oechslin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paaladinesh","family":"Thavendiranathan","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging, University Medical Imaging Toronto, Toronto General Hospital, Toronto, ON, Canada"},{"name":"Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-7888","authenticated-orcid":false,"given":"Gauri R.","family":"Karur","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, University of Toronto, Toronto, ON, Canada"},{"name":"Joint Department of Medical Imaging, University Medical Imaging Toronto, Toronto General Hospital, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31553"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e3182342316"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14245"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.05.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.07.006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2018.04.006"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.16019"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.32"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02699-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/352337a0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1116"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv073"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.10.010"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq127"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003705"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.682390"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.10.033"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.095"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.396"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.888636"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2021.11.010"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153824"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001106"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.122.003978"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-023-01343-7"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.72"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.03.053"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14522"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8010013"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61094"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.icvts.2003.11.015"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1212CI"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13665-020-00248-w"}],"container-title":["Canadian 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