{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:08:01Z","timestamp":1787018881094,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    Adrenocortical carcinoma (ACC) is a rare condition with a poor and hardly predictable prognosis. This study aims to build and evaluate a preoperative computed tomography (CT)-based score (CT score) using features previously reported as biomarkers in ACC to predict overall survival (OS) in patients with ACC.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A CT score based on preoperative CT examinations combining shape elongation, maximum tumour diameter, and the European Network for the Study of Adrenal Tumors (ENSAT) stage was built using a logistic regression model to predict OS duration in a development cohort of 89 patients with ACC. An optimal cut-off of the CT score was defined and the Kaplan-Meier method was used to assess OS. The CT score was then tested in an external validation cohort of 54 patients wit ACC. The C-index of the CT score for predicting OS was compared to that of ENSAT stage alone.\n                    <jats:bold>Results:<\/jats:bold>\n                    The CT score helped discriminate between patients with poor prognosis and patients with good prognosis in both the validation cohort (54 patients; mean OS, 69.4 months; 95% confidence interval [CI]: 57.4-81.4 months vs mean OS, 75.6 months; 95% CI: 62.9-88.4 months, respectively;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .022). In the validation cohort the C-index of the CT score was significantly better than that of the ENSAT stage alone (0.62 vs 0.35;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .002).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    A CT score combining morphological criteria, radiomics, and ENSAT stage on preoperative CT examinations allows a better prognostic stratification of patients with ACC compared to ENSAT stage alone.\n                  <\/jats:p>","DOI":"10.1177\/08465371251335170","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T10:49:53Z","timestamp":1746355793000},"page":"683-691","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["A Computed Tomography-Based Score to Predict Survival in Patients With Adrenocortical Carcinoma: A Proof-of-Concept Study"],"prefix":"10.1177","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-0875","authenticated-orcid":false,"given":"Maxime","family":"Barat","sequence":"first","affiliation":[{"name":"Department of Radiology, H\u00f4pital Cochin, AP-HP, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Eltaher","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed W.","family":"Moawad","sequence":"additional","affiliation":[{"name":"Mercy Catholic Medical Center, Darby, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-1682","authenticated-orcid":false,"given":"Philippe","family":"Soyer","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Cochin, AP-HP, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fuentes","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Golse","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Cochin, AP-HP, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Jouinot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"},{"name":"Department of Endocrinology, H\u00f4pital Cochin, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayahallah A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa A.","family":"Shehata","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Assi\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"},{"name":"Department of Endocrinology, H\u00f4pital Cochin, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohab M.","family":"Elmohr","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, 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