{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:25:06Z","timestamp":1777476306782,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    This study aims to evaluate the outcomes of breast MRI-guided vacuum assisted biopsies (MVAB) performed on lesions with high T2 signal.\n                    <jats:bold>Materials and Methods:<\/jats:bold>\n                    We retrospectively collected of all MVAB performed at our institution between January 2016 and December 2021 for high T2 lesions. T2 hyperintensity was defined as equal or higher signal than normal lymph node. The correlation between various demographic and imaging characteristics and the binary pathological outcome (benign vs malignant) was evaluated.\n                    <jats:bold>Results:<\/jats:bold>\n                    In total, 174 biopsies from 165 women met the inclusion criteria and were included in the cohort. Malignancy was detected in 35 lesions (20%), most commonly ductal carcinoma in situ (DCIS, 57%), followed by infiltrating ductal carcinoma (IDC, 40%). The most common benign diagnosis was fibrocystic changes (FCC, 38%). In 19 lesions MVAB detected high-risk pathology, 3 of which were upgraded to malignancy. Older age (Mean 61 vs 54 years,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .04), washout kinetics (29% vs 13%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .01), and indication for extent of disease evaluation (53% vs 32%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .06) were the strongest predictors of malignancy. Lesion size and morphology were not significantly associated with outcome.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Given the considerable cancer rate, T2 hyperintensity should be used with caution as a benign indicator and not as a sole criterion for ruling out malignancy. Additional factors such as patient age, kinetic features, and MRI indication should be considered to improve diagnostic accuracy.\n                  <\/jats:p>","DOI":"10.1177\/08465371251346137","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T11:02:20Z","timestamp":1750330940000},"page":"180-186","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["T2 Hyperintense Lesions on Breast MRI \u2013 Is the Assumption of Benignity Justified?"],"prefix":"10.1177","volume":"77","author":[{"given":"Yulia","family":"Nechyporenko","sequence":"first","affiliation":[{"name":"Department of Radiology, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Golan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tehillah S.","family":"Menes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-0861","authenticated-orcid":false,"given":"Vivianne A. 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