{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:36:07Z","timestamp":1777476967565,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The precentral cortex normally demonstrates lower signal intensity compared to remainder of the neocortex on 2D fluid attenuated inversion recovery (FLAIR) images. Loss of this normal hypointensity bilaterally can be seen in patients with adult hypoxic-ischemic brain injury (HIBI). We have named this the \u2018FLAIR motor\u2019 sign (FMS). The performance of this sign for detection of HIBI is evaluated in this case-control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>MRI studies of 74 consecutive patients with clinical evidence of HIBI following cardiac arrest formed the \u2018case\u2019 group. Controls comprised of normal MRI studies of an equal number of age and gender matched patients. Two fellowship-trained neuro-radiologists reviewed the MRI studies in a blinded randomized fashion and recorded the presence or absence of \u2018FLAIR motor\u2019 sign.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Average time from cardiac arrest to MRI was 7.12 days (range: 1-25 days). The average sensitivity and specificity of \u2018FLAIR motor\u2019 sign for HIBI was 86.49% and 100% respectively. The sign demonstrated excellent inter-reader agreement (kappa &gt;0.8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The loss of the normal hypointensity in bilateral pre-central cortex on 2D-FLAIR images is a specific and reliable MRI sign of HIBI in the subacute phase following cardiac arrest in adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08465371251352699","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:45:56Z","timestamp":1752075956000},"page":"212-217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The \u2018FLAIR Motor Sign\u2019: FLAIR Signal Abnormality in Precentral Cortex is Useful to Diagnose Adult Global Hypoxic-Ischemic Brain Injury Following Cardiac Arrest"],"prefix":"10.1177","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-8270","authenticated-orcid":false,"given":"Jaykumar Raghavan","family":"Nair","sequence":"first","affiliation":[{"name":"Department of Radiology, QEII Health Science Centre, Halifax Infirmary Hospital, Dalhousie University, NS, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Abdulla","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Bharatha","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, St. Michael\u2019s Hospital, University of Toronto, ON, Canada"},{"name":"Li Ka Shing Knowledge Institute, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-3341","authenticated-orcid":false,"given":"Shobhit","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, St. Michael\u2019s Hospital, University of Toronto, ON, Canada"},{"name":"Li Ka Shing Knowledge Institute, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2012.08.002"},{"issue":"6","key":"e_1_3_3_3_2","first-page":"999","article-title":"Diffusion-weighted MR imaging of global cerebral anoxia","volume":"20","author":"Arbelaez A","year":"1999","unstructured":"Arbelaez A, Castillo M, Mukherji SK. 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