{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:15:35Z","timestamp":1783556135341,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Local tumour progression (LTP) after percutaneous ablation of small renal cell carcinoma (RCC) is suspected when new enhancing or enlarging soft tissue appears within the ablation zone. Benign post-treatment changes can mimic this finding. This study compares the incidence and imaging characteristics of non-malignant changes (NMC) versus LTP after renal ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In this single-center, retrospective study, all patients with RCC treated with radiofrequency ablation (RFA) from February 2004 to May 2016 were identified. Post-ablation imaging reports from through May 2017 were reviewed to detect findings suspicious for LTP. Patients with suspicious findings underwent clinical, imaging, and histopathologic follow-up through May 2025 to determine the reference diagnosis. Imaging features were categorized by morphology, location within the ablation zone, and enhancement pattern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 256 patients (mean age 65.6\u2009years\u2009\u00b1\u200910.8, 193 men) with 268 treated tumours, 18 tumours (6.7%) developed suspicious imaging findings. Eight tumours (3.0%) were classified as NMC and 10 tumours (3.7%) as LTP. NMC had significantly lower CT enhancement than LTP (31 vs 152 HU,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Lesions along the renal parenchymal margin were exclusively associated with LTP (9\/9), whereas abnormalities at the extrarenal margin or centrally within the ablation zone were predominantly NMC (8\/9). Enhancement with washout was seen only in LTP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Non-malignant post-ablation changes can mimic LTP and occur with similar frequency. Imaging features can help differentiate benign changes from local tumour progression and reduce unnecessary re-interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08465371261418513","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:01:51Z","timestamp":1769842911000},"page":"499-507","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-Malignant Imaging Changes Mimicking Local Tumour Progression of Renal Cell Carcinoma Following Percutaneous Ablation"],"prefix":"10.1177","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-3553","authenticated-orcid":false,"given":"Derek W.","family":"Cool","sequence":"first","affiliation":[{"name":"Division of Interventional Radiology, Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1459-5282","authenticated-orcid":false,"given":"Cathal N.","family":"O\u2019Leary","sequence":"additional","affiliation":[{"name":"Division of Vascular and Interventional Radiology, Joint Department of Medical Imaging, University of Toronto, University Health Network, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6603-7621","authenticated-orcid":false,"given":"Satheesh","family":"Krishna","sequence":"additional","affiliation":[{"name":"Division of Abdominal Imaging, Joint Department of Medical Imaging, University of Toronto, University Health Network, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Kachura","sequence":"additional","affiliation":[{"name":"Division of Vascular and Interventional Radiology, Joint Department of Medical Imaging, University of Toronto, University Health Network, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001911"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.7760"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.07.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.05.010"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2019.11.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132958"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1363843"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2019190083"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11608.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2007.06.019"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2013.07.006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-020-02639-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.05.051"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000463826"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11246.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2024.0849"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.6374"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-018-1541-0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1678193"}],"container-title":["Canadian Association of Radiologists Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08465371261418513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08465371261418513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08465371261418513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T23:23:56Z","timestamp":1783553036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08465371261418513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/08465371261418513"],"URL":"https:\/\/doi.org\/10.1177\/08465371261418513","relation":{},"ISSN":["0846-5371","1488-2361"],"issn-type":[{"value":"0846-5371","type":"print"},{"value":"1488-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]}}}