{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:45:35Z","timestamp":1792575935756,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To identify CT features that may help discriminate between pancreatic adenosquamous carcinoma (PASC) and pancreatic ductal adenocarcinoma (PDAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>CT examinations of 42 patients with PASC were analyzed by 2 independent readers and compared to those obtained in 42 patients with PDAC. Sensitivity, specificity, and accuracy of each variable for diagnosing PASC versus PDAC were calculated. Associations between variables and PASC were examined using univariable and multivariable analyses. A CT signature was developed to distinguish PASC from PDAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      PASC presented as single (100%), oval (93%), and heterogeneously enhancing (98%) pancreatic mass with a mean largest diameter of 46.2\u2009\u00b1\u200918.5\u2009mm, vessel encasement (69%), and segmental portal hypertension (64%), in association with hepatic metastases (52%). In univariable analysis, ring enhancement (odds ratio [OR], 25.23;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.002), internal necrosis (OR, 9.48;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), heterogeneous tumour enhancement (OR, 25.23;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.002), and segmental portal hypertension (OR, 4.5;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001), were the most discriminating CT findings for the diagnosis of PASC. In multivariable analysis, internal necrosis (adjusted OR, 5.44; 95% confidence interval [CI]: 1.83-17.34;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.003), heterogeneous tumour enhancement (adjusted OR, 8.80; 95% CI: 1.41-171.47;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.049), and segmental portal hypertension (adjusted OR, 2.96; 95% CI: 1.02-8.97;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.048), were independent variables strongly associated with the diagnosis of PASC. The CT signature yielded 81% sensitivity (95% CI: 66-91), 74% specificity (95% CI: 58-86), and area under the receiver operating characteristic curve of 0.840 (95% CI: 0.756-0.924) for diagnosing PASC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CT examination demonstrates several features that help discriminate between PASC and PDAC. A CT signature based on 3 imaging features can help distinguish PASC from PDAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08465371261426959","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:49:04Z","timestamp":1773902944000},"page":"715-726","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Differentiating Between Pancreatic Adenosquamous Carcinoma and Pancreatic Ductal Adenocarcinoma Using Computed Tomography"],"prefix":"10.1177","volume":"77","author":[{"given":"Marwa","family":"Alkatheeri","sequence":"first","affiliation":[{"name":"Department of Radiology, H\u00f4pital Cochin, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-0875","authenticated-orcid":false,"given":"Maxime","family":"Barat","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Cochin, AP-HP, Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Moyne","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Cochin, AP-HP, Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pellat","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, France"},{"name":"Department of Gastroenterology, H\u00f4pital Cochin, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Dohan","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Cochin, AP-HP, Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, 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