{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:25:04Z","timestamp":1777922704757,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Rui Liu","award":["SYS2019109"],"award-info":[{"award-number":["SYS2019109"]}]},{"name":"Rui Liu","award":["XZR2020039"],"award-info":[{"award-number":["XZR2020039"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The clinical features of viral respiratory infections in individuals with rheumatic immune diseases, renal diseases, hematological diseases, and healthy individuals were analyzed. Additionally, the impact of immunosuppressive therapy on the clinical manifestations of viral respiratory infections was explored. Patients attending the outpatient clinic of the Department of Rheumatology and Immunology at Suzhou Hospital of Traditional Chinese Medicine from October 1, 2023, to May 1, 2024, as well as healthy individuals undergoing physical examinations, were selected for the study. Data were collected through questionnaires, including information on viral respiratory infections, vaccination status, clinical symptoms, and medication use. A total of 425 questionnaires were collected. There were significant differences among groups in recovery time, disease classification, vaccination rates, and specific clinical symptoms (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.05). Immunosuppressive therapy significantly reduced the incidence of runny nose (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.046) and chills (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001) but was associated with a higher proportion of ordinary cases, suggesting that it may be associated with increased disease severity (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.012). Multivariate logistic regression analysis showed that the use of glucocorticoids significantly prolonged both recovery time (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.007) and duration of cough (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.044). The rheumatology group experienced shorter recovery time (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.016) and a lower risk of fever (38\u00b0C\u201339\u00b0C), whereas the hematology group had an increased risk of high fever (&gt;39\u00b0C;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.037). Vaccination significantly increased the likelihood of mild cases (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.041), serving as an important protective factor. Additionally, younger patients and females tended to exhibit relatively more severe clinical manifestations. Significant differences between the groups existed in terms of symptomatology, clinical symptoms, and time to recovery, and the use of immunosuppressive therapy, especially glucocorticoids, may have exacerbated the patient\u2019s condition. Vaccination provided a protective effect for patients undergoing immunosuppressive therapy, mitigating the condition to a certain extent.\n                  <\/jats:p>","DOI":"10.1177\/08828245251407696","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:03:34Z","timestamp":1767092614000},"page":"26-36","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Influencing Factors of Viral Respiratory Infection in Patients Undergoing Immunosuppressive Therapy"],"prefix":"10.1177","volume":"39","author":[{"given":"Ming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Soochow University, Suzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0256-4746","authenticated-orcid":false,"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221916"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1739306"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020293"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1439242"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-022-05123-2"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220647"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-020-00313-6"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116178"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0709-x"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(09)70175-6"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00672-y"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-30"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1170035"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.853009"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2319566121"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12020138"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD014914.pub2"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12111270"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.001"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00479-7"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(20)30196-1"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-091919-092720"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01643-9"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2022.107042"}],"container-title":["Viral Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08828245251407696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08828245251407696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08828245251407696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:24Z","timestamp":1777667304000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08828245251407696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/08828245251407696"],"URL":"https:\/\/doi.org\/10.1177\/08828245251407696","relation":{},"ISSN":["0882-8245","1557-8976"],"issn-type":[{"value":"0882-8245","type":"print"},{"value":"1557-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]}}}