{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:29:22Z","timestamp":1787243362205,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Program for Youth Innovation in Future Medicine, Chongqing Medical University","award":["W0160"],"award-info":[{"award-number":["W0160"]}]},{"name":"Scientific Research Project on Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine of Tianjin Municipal Health Commission","award":["2023204"],"award-info":[{"award-number":["2023204"]}]},{"name":"Scientific Research Program of Hebei Provincial Administration of Traditional Chinese Medicine","award":["T2025060"],"award-info":[{"award-number":["T2025060"]}]},{"name":"The Science & Technology Development Fund of Tianjin Education Commission for Higher Education","award":["2021KJ204"],"award-info":[{"award-number":["2021KJ204"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Viral Immunology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    This study aimed to characterize Epstein\u2013Barr virus (EBV) serological markers and EBV DNA profiles in a healthy examination cohort from Chongqing, China, and to examine their associations with routine hematological and biochemical parameters. This retrospective cross-sectional study included adults undergoing routine health examinations in Chongqing between 2019 and 2024. EBV serology (EA-IgA and VCA-IgA) was assessed in 4,535 individuals using ELISA, and EBV DNA was measured in 6,508 individuals by quantitative PCR. Hematological indices and liver and renal function markers were compared across EBV antibody subgroups and EBV DNA status. Multivariable linear regression analyses were performed with adjustment for age and sex. VCA-IgA seroprevalence was significantly higher than EA-IgA (13.38% vs. 6.09%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001), with both peaking in the 41\u201350-year age group. EBV DNA was detected in 7.24% of individuals, with positivity increasing with age (\u226561 years: 12.09%) and being higher in males than females (7.81% vs. 6.06%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.010). Among EBV DNA\u2013positive individuals, 86.17% had low viral loads (&lt;10\n                    <jats:sup>4<\/jats:sup>\n                    copies\/mL). After adjustment, EBV seropositivity and EBV DNA positivity were independently associated with statistically significant differences in leukocyte subsets and hepatic and renal markers; however, all median values remained within established clinical reference ranges. EBV infection markers in this inland Chinese health examination population exhibited distinct age- and sex-related distributions and showed independent associations with subtle physiological variations rather than overt pathology. Importantly, EBV serological markers and EBV DNA demonstrated differential association patterns, indicating that they convey complementary and nonredundant biological information in assessing EBV infection status.\n                  <\/jats:p>","DOI":"10.1177\/08828245261426990","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:22:58Z","timestamp":1773224578000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serological Markers and EBV DNA of Epstein\u2013Barr Virus Infection in a Health Examination Cohort from Chongqing, China"],"prefix":"10.1177","volume":"39","author":[{"given":"Zhuojun","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin\u2019s Clinical Research Center for Cancer, Tianjin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Center for Clinical Molecular Medical Detection, Engineering Research Center of Chongqing Education Commission of China for IVD Technology Innovation and Translation, Laboratory Medicine Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanxin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4955-2899","authenticated-orcid":false,"given":"Yu","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 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