{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:11:52Z","timestamp":1789827112073,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Viral Immunology"],"abstract":"<jats:p>\n                    Human herpesvirus-6 (HHV-6) is involved in immune modulation and contributes to cancer development through interactions with host genetic factors. Hepcidin (\n                    <jats:italic toggle=\"yes\">HAMP<\/jats:italic>\n                    ) and NRAMP1 genes play essential roles in iron metabolism and innate immunity, yet their polymorphisms remain poorly investigated in HHV-6\u2013associated cancers. This study investigated the association between\n                    <jats:italic toggle=\"yes\">HAMP<\/jats:italic>\n                    and NRAMP1 gene polymorphisms and HHV-6 infection in 40 confirmed HHV-6\u2013positive cancer patients compared with 40 non-cancer, HHV-6\u2013negative controls. Genomic DNA was extracted and verified by agarose gel electrophoresis. Hepcidin polymorphisms were analyzed using Tetra-ARMS PCR, while NRAMP1 (3\u2032UTR) polymorphism was detected by PCR-RFLP. Cancer patients exhibited wild-type, mutant, and heterozygous hepcidin genotypes, whereas controls predominantly showed the wild-type genotype. Although allele frequency analysis revealed no statistically significant difference for the G and TG\n                    <jats:sup>+<\/jats:sup>\n                    alleles between groups (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.23), the hepcidin A allele (521 bp) was more frequent among cancer patients, suggesting a possible association with increased cancer susceptibility (odds ratio = 2.111). For NRAMP1, three genotypic patterns were identified (TG\u2212\/TG\u2212, TG+\/TG+, and TG\u2212\/TG+), and while no significant between-group difference was detected (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.23), the TG+ allele demonstrated a potential two-fold increased cancer risk among carriers. These findings suggest that specific allelic variants\u2014particularly the hepcidin A allele and NRAMP1 TG+ allele\u2014may contribute to cancer susceptibility in HHV-6\u2013infected individuals, highlighting a possible genetic\u2013viral interaction that influences immune and iron-regulatory pathways in cancer development.\n                  <\/jats:p>","DOI":"10.1177\/08828245261487718","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:41:55Z","timestamp":1789645315000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Variants of NRAMP1 and Hepcidin (\n                    <i>HAMP<\/i>\n                    ) in Cancer Patients Infected with Human Herpesvirus-6"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1940-5060","authenticated-orcid":false,"given":"Nadia Habeeb","family":"Sarhan","sequence":"first","affiliation":[{"name":"Research Laboratory of Environmental Toxicology Microbiology and Health (LR17ES06), Faculty of Sciences, Sfax University, Sfax 3000, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Jabbar Yasir","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, College of Medicine, University of Kufa, Najaf 54001, Iraq."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhouane","family":"Gdoura","sequence":"additional","affiliation":[{"name":"Research Laboratory of Environmental Toxicology Microbiology and Health (LR17ES06), Faculty of Sciences, Sfax University, Sfax 3000, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"4","key":"e_1_3_2_2_1","first-page":"1574","article-title":"Immune-expression of estrogen receptors alpha in oral mucosa among Sudanese patients with breast cancer","volume":"14","author":"Abbas AM","year":"2020","unstructured":"Abbas AM, , Shalabi MG, , Elsedeg SA, et al. Immune-expression of estrogen receptors alpha in oral mucosa among Sudanese patients with breast cancer. 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