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Vigabatrin was administered upon diagnosis, starting with a 50-mg\/kg\/day dose and increasing 50 mg\/kg every 48 hours to reach a maximum dose of 200 mg\/kg\/day. Twenty-nine percent of cases were considered to be cryptogenic or idiopathic West syndrome, while 70.7% were symptomatic. Response to vigabatrin treatment was measured according to five categories: (1) seizures free: 61.8% of cases for cryptogenic and 29.3% for symptomatic West syndrome, (2) more than 75% reduction in the number of infantile spasms: 14.7% for cryptogenic and 26.8% for symptomatic West syndrome, (3) from 50% to 74% reduction in the number of infantile spasms: 11.8% for cryptogenic and 24.4% for symptomatic West syndrome, (4) poor or null response: 11.8% for cryptogenic and 18.3% for symptomatic West syndrome, and (5) increase in the number of infantile spasms: one symptomatic case (1.2%). All seizure-free cryptogenic cases showed normal neuropsychic development. The most effective dose of vigabatrin was 150 mg\/kg of body weight per day. The most frequent adverse events were somnolence in 19 cases and irritability in 15 cases, but none required treatment interruption. (J Child Neurol 2000;15:161-165).<\/jats:p>","DOI":"10.1177\/088307380001500304","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T19:24:33Z","timestamp":1201202673000},"page":"161-165","source":"Crossref","is-referenced-by-count":41,"title":["Vigabatrin as a First-Choice Drug in the Treatment of West Syndrome"],"prefix":"10.1177","volume":"15","author":[{"given":"Natalio","family":"Fejerman","sequence":"first","affiliation":[{"name":"Hospital J.P. Garrahan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Cers\u00f3simo","sequence":"additional","affiliation":[{"name":"Hospital J.P. 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