{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:14:46Z","timestamp":1791936886564,"version":"4.3.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>\n                    We describe the clinical utility of echo-planar diffusion-weighted imaging in neonatal cerebral infarction. Eight full-term neonates aged 1 to 8 days referred for neonatal seizures were studied. Patients were followed for a mean of 17 months with detailed neurologic examinations at regular intervals. Head computed tomography (CT) and conventional magnetic resonance (MRI) and diffusion-weighted images were obtained. Percent lesion contrast was evaluated for 19 lesions on T\n                    <jats:sub>2<\/jats:sub>\n                    -weighted and diffusion-weighted images. Follow-up conventional MRIs were obtained in seven patients. The findings on diffusion-weighted imaging were correlated with CT and conventional MRI findings as well as with short-term neuro-developmental outcome. Four patients had focal cerebral infarctions. Four patients had diffuse injury consistent with hypoxic-ischemic encephalopathy. Percent lesion contrast of all 19 lesions was significantly higher on diffusion-weighted images when compared with T\n                    <jats:sub>2<\/jats:sub>\n                    -weighted images. In five patients, there were lesions visualized only with diffusion-weighted imaging. In all patients, there was increased lesion conspicuity and better definition of lesion extent on the diffusion-weighted images compared with the CT and T\n                    <jats:sub>2<\/jats:sub>\n                    -weighted MR images. In seven of eight patients follow-up imaging confirmed prior infarctions. Short-term neurologic outcome correlated with the extent of injury seen on the initial diffusion-weighted imaging scans for all patients. Diffusion-weighted imaging is useful in the evaluation of acute ischemic brain injury and seizure etiology in neonates. In the acute setting, diffusion-weighted imaging provides information not available on CT and conventional MRI. This information correlates with short-term clinical outcome. (J Child Neurol 2000;15:592-602).\n                  <\/jats:p>","DOI":"10.1177\/088307380001500905","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T19:24:33Z","timestamp":1201202673000},"page":"592-602","source":"Crossref","is-referenced-by-count":45,"title":["Diffusion-Weighted Imaging in Neonatal Cerebral Infarction: Clinical Utility and Follow-Up"],"prefix":"10.1177","volume":"15","author":[{"given":"Kalpathy S.","family":"Krishnamoorthy","sequence":"first","affiliation":[{"name":"Pediatric Neurology Unit, Departments of Neurology and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teesta B.","family":"Soman","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Departments of Neurology and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Takeoka","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Departments of Neurology and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela W.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Radiology (Neuroradiology Division) Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.159.3.1503032"},{"key":"atypb2","first-page":"1097","volume":"13","author":"Chien D.","year":"1992","journal-title":"AJNR Am J Neuroradiol"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.40"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.188.3.8351338"},{"key":"atypb5","first-page":"1107","volume":"16","author":"Matsumoto K.","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.185.3.1438745"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.1.r99ja02155"},{"key":"atypb8","first-page":"1061","volume":"19","author":"Lovblad KO","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.2.8668785"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880080411"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6766"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70251-9"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1073018"},{"key":"atypb14","volume-title":"The Neurological Examination of the Full Term Newborn Infant","author":"Pretchl Hfr","year":"1964"},{"key":"atypb15","volume-title":"Saint-Anne D (eds): The Neurological Examination of the Infant","author":"Andre T.","year":"1960"},{"key":"atypb16","first-page":"471","author":"Paine RS","year":"1964","journal-title":"Pediatr Clin North Am"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.2.8668784"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910310209"},{"key":"atypb19","unstructured":"Latchow RE: Image quality in clinical magnetic resonance imaging, in MR and CT Imaging of the Head, Neck and Spine. 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