{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T09:59:24Z","timestamp":1777802364804,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>\n                    We report a 15-year-old boy who presented with recurrent headaches associated with numbness, confusion, and speech difficulty. Brain magnetic resonance imaging (MRI) revealed diffuse bilateral white-matter hyperintensity on fluid-attenuated inversion-recovery and T\n                    <jats:sub>2<\/jats:sub>\n                    -weighted images in the internal capsule, periventricular and subcortical white matter, base of the pons, and middle cerebellar peduncles. Lesions were isointense on T\n                    <jats:sub>1<\/jats:sub>\n                    weighted images and nonenhancing. Muscle biopsy showed changes consistent with a mitochondrial myopathy. Mitochondrial respiratory chain enzyme activity analysis revealed a significant reduction in complex II activity. Genetic testing was negative. We conclude that mitochondrial encephalomyopathy may present with unusual diffuse supratentorial and infratentorial white-matter changes on MRI. (J Child Neurol 2002;17:47-49).\n                  <\/jats:p>","DOI":"10.1177\/088307380201700112","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T18:40:10Z","timestamp":1206988810000},"page":"47-49","source":"Crossref","is-referenced-by-count":12,"title":["Diffuse Magnetic Resonance Imaging White-Matter Changes in a 15-Year-Old Boy With Mitochondrial Encephalomyopathy"],"prefix":"10.1177","volume":"17","author":[{"given":"Arie","family":"Weinstock","sequence":"first","affiliation":[{"name":"Department of Neurology Children's Hospital of Buffalo State University of New York at Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Giglio","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital of Buffalo State University of New York at Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital of Buffalo State University of New York at Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Department of Neurology and Imaging Services Millard Fillmore and Buffalo General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Januario","sequence":"additional","affiliation":[{"name":"Department of Radiology Kaleida Health Children's Hospital of Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Balos","sequence":"additional","affiliation":[{"name":"Department of Pathology Buffalo General Hospital Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"atypb1","volume-title":"Inborn errors of metabolism of the nervous system","author":"Evans OB","year":"2000"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160409"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199612)19:12<1603::AID-MUS10>3.0.CO;2-S"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7167"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199912)46:6<916::AID-ANA16>3.0.CO;2-R"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.4.512"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.1.293"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400318"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1159\/000117128"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.2.233"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.166.3.8623642"},{"key":"atypb12","first-page":"1119","volume":"14","author":"Barkovich JA","year":"1993","journal-title":"AJNR Am J Neuroradiol"},{"key":"atypb13","first-page":"375","volume":"12","author":"Sandhu FS","year":"1991","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307380201700112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307380201700112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:32:36Z","timestamp":1777494756000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/088307380201700112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1177\/088307380201700112"],"URL":"https:\/\/doi.org\/10.1177\/088307380201700112","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}