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A thorough metabolic evaluation of defined leukodystrophies, including Krabbe's disease, adrenoleukodystrophy, metachromatic leukodystrophy, Canavan's disease, and Leigh disease, was negative. A diagnosis of Alexander's disease was made based on the clinical features and ruling out all other possible causes. It was confirmed by pathologic findings of numerous subpial, subependymal, and perivascular Rosenthal fibers throughout the entire cerebrum. Interestingly, autopsy also identified the stenotic sylvian aqueduct owing to Rosenthal fiber accumulation, explaining the origin of hydrocephalus. The evolution of magnetic resonance imaging findings appears to be unique in this disease. (J Child Neurol 2002;17:463-466).<\/jats:p>","DOI":"10.1177\/088307380201700615","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T18:40:10Z","timestamp":1206988810000},"page":"463-466","source":"Crossref","is-referenced-by-count":11,"title":["Infantile Alexander's Disease: Serial Neuroradiologic Findings"],"prefix":"10.1177","volume":"17","author":[{"given":"Qing","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen S.","family":"Johns","sequence":"additional","affiliation":[{"name":"Department of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anantha","family":"Manepalli","sequence":"additional","affiliation":[{"name":"Department of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Radiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Geller","sequence":"additional","affiliation":[{"name":"Department of Neurology Saint Louis University Hospital Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/72.3.373"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389300800205"},{"key":"atypb3","first-page":"122","volume":"10","author":"Arend AO","year":"1991","journal-title":"Clin Neuropathol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1999.tb07338.x"},{"key":"atypb5","unstructured":"Johnson AB: Alexander disease, in Moser HW (ed): Neurodystrophies and Neurolipidoses. 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