{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:36:41Z","timestamp":1790303801748,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>\n                    Subacute sclerosing panencephalitis is an almost universally fatal late complication of measles infection for which there is no established treatment. We report a patient with subacute sclerosing panencephalitis who was bed-bound and ataxic and had a left hemiparesis and frequent myoclonus. He was started on a new regimen consisting of intraventricular interferon-\u03b1 (starting at 100,000 U\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/day, building up to 1 million U\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/day), ribavirin (60 mg\/kg\/day intravenously), and inosiplex (3 g\/day) and improved markedly. At 10 weeks, the intraventricular reservoir was removed because of bacterial infection, and he was discharged home on oral ribavirin (1200 mg\/kg\/day) and inosiplex. He continued to improve as judged by neurologic examination, functional independence measurement, neuropsychometry and single photon emission computed tomography (SPECT) imaging. However, after 10 months, he deteriorated suddenly and died before further intraventricular treatment could be instituted. Further trials are needed to evaluate long-term combination therapy in subacute sclerosing panencephalitis. (J Child Neurol 2002;17:703-705).\n                  <\/jats:p>","DOI":"10.1177\/088307380201700911","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T18:40:10Z","timestamp":1206988810000},"page":"703-705","source":"Crossref","is-referenced-by-count":35,"title":["Treatment of Subacute Sclerosing Panencephalitis With Interferon-\u03b1, Ribavirin, and Inosiplex"],"prefix":"10.1177","volume":"17","author":[{"given":"Tom","family":"Solomon","sequence":"first","affiliation":[{"name":"Departments of Neurological Science and Medical Microbiology and Genitourinary Medicine University of Liverpool Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Anthony","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Genitourinary Medicine University of Liverpool Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobhan","family":"Vinjamuri","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department Royal Liverpool University Hospital Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Beeching","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit University Hospital Aintree Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Malucci","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Walton Centre for Neurology and Neurosurgery Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Humphrey","sequence":"additional","affiliation":[{"name":"Department of Neurology Walton Centre for Neurology and Neurosurgery Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0387-7604(93)90120-W"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389701200803"},{"key":"atypb3","volume-title":"Subacute sclerosing panencephalitis","author":"Houff SA","year":"2001"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1988.tb03639.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.4.653"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.4.748"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(00)00233-2"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03150250078007"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1097\/00013614-198604000-00007"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb07377.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-9091(96)80030-1"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1086\/317531"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7280.183"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.59.2.472-478.1986"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/088307380101601206"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.488"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/138.2.249"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(97)00055-7"},{"key":"atypb19","unstructured":"Banks G., Fernandez H.: Clinical use of ribavirin in measles: A summarized review, in Smith RA, Knight V, Smith JAD (eds): Clinical Applications of Ribavirin. New York, Academic Press , 1984, 203-209."},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/16.5.654"},{"key":"atypb21","volume-title":"Investigational Drug Brochure, Intravenous Ribavirin","author":"ICN Pharmaceuticals","year":"1998"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92590-0"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.943-945.2001"},{"key":"atypb24","volume-title":"Subacute sclerosing panencephalitis","author":"Solomon T.","year":"2002"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307380201700911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307380201700911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:33:40Z","timestamp":1777494820000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/088307380201700911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1177\/088307380201700911"],"URL":"https:\/\/doi.org\/10.1177\/088307380201700911","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}